424 BIOL PSYCHIATRY 1991 ;30:424-426 impaired Neuropsychological Symptomatic Volunteers with Preliminary Findings Functioning Schizotypy: in Michael J. Lyons, Mary E. Merla, Leslie Young, and William S. Kremen Introduction Rado's concept of schizotypy was used by Meehl (1962) to describe individuals who are not psy- chotic but are vulnerable to schizophrenia. Meehl hypothesized that those with the vulnerability, though not schizophrenic, might have cognitive or psychophysiological charzcteristics reflecting an association with schizophrenia. Consistent with Meehl's theory, abnormalities in eye trac' if-L: sustained attention, and visual masking h. • been well documented in both schizophrer:~ and schizotypy. Impaired Wisconsin Card ~ ag Test (WCST) (Grant and Berg 1948) pe~~ r_ mance has also been found in schizophrenia. The WCST requires concept formation and cog- nitive flexibility, and performance appears to be associated with relatively selective activation of dorsolateral prefrontal cortex (Weinberger et al 1986). The WCST is of interest vis-h-vis schi- zotypy because of its cognitive demands and its link to a brain region implicated in schizophre- nia. Spaulding et al (1989) found impairment on a modified WCST in Minnesota Multiphasic Personality Inventory (MMPI)-defined schizo- From Boston University (MJL, MEM, LY) and Harvard Medical School (MJL, MEM, WSK) and Brockton--West Roxbury V.A. Medical Center (WSK), Boston, MA. Address reprint requests to Michael Lyons: Ph.D., Department of Psychology, BostonUniversity, 64 CummingtonSt., Boston, MA 02215. Received March 23, 1991; revised April 27, 1991. typy. We report on WCST performance in schi- zotypic su~ects recruited using a novel method. ;~Aethods Measures The StructurM hi~erview for Schizotypy (SIS) (Kendler et al 1989) was developed to assess schizotypal signs and symptoms. Each symptom is rated on a seven-point scale from "absent" to "severe." The WCST tests the ability to estab- lish and shift mental sets. Subjects sort cards on the basis of color, form, or number. They are not told of the correct sorting principle but are simply told whether each sort is correct. Ten correct consecutive sorts constitute a completed category. After completion of a category, the sorting principle changes; however, the exam- inee is not informed of the change and must discern the principle only by examiner feed- back. The WCST was scored according to Hea- ton's (1981) rules. Subjects Undergraduate students aged 18-22 were re- cruited through an advertisement in a university newspaper and from volunteers taking Intro- ductory Psychology. The advertisement solic- ited subjects who believed they had "ESP, te- © 1991 Society of Biological Psychiatry 0006-3223/91/$03.50