666e Plastic and Reconstructive Surgery฀•฀October฀2014 11.฀ Longaker฀MT,฀Adzick฀NS.฀The฀biology฀of฀fetal฀wound฀heal- ing:฀A฀review.฀Plast Reconstr Surg.฀1991;87:788–798. 12.฀ Lorenz฀HP,฀Longaker฀MT,฀Perkocha฀LA,฀Jennings฀RW,฀Har- rison฀MR,฀Adzick฀NS.฀Scarless฀wound฀repair:฀A฀human฀fetal฀ skin฀model.฀Development฀1992;114:253–259. 13.฀Lorenz฀ HP,฀ Whitby฀ DJ,฀ Longaker฀ MT,฀ Adzick฀ NS.฀ Fetal฀ wound฀healing:฀The฀ontogeny฀of฀scar฀formation฀in฀the฀non- human฀primate.฀Ann Surg.฀1993;217:391–396. 14.฀ Stern฀ M,฀ Dodson฀ TB,฀ Longaker฀ MT,฀ Lorenz฀ HP,฀ Harrison฀ MR,฀ Kaban฀ LB.฀ Fetal฀ cleft฀ lip฀ repair฀ in฀ lambs:฀ Histologic฀ characteristics฀ of฀ the฀ healing฀ wound.฀ Int J Oral Maxillofac Surg.฀1993;22:371–374. 15.฀ Longaker฀ MT,฀ Whitby฀ DJ,฀ Ferguson฀ MW,฀ Lorenz฀ HP,฀ Har- rison฀MR,฀Adzick฀NS.฀Adult฀skin฀wounds฀in฀the฀fetal฀environ- ment฀heal฀with฀scar฀formation.฀Ann Surg.฀1994;219:65–72. ฀16.฀ Longaker฀ MT,฀ Bouhana฀ KS,฀ Harrison฀ MR,฀ Danielpour฀ D,฀ Roberts฀AB,฀Banda฀MJ.฀Wound฀healing฀in฀the฀fetus:฀Possible฀ role฀for฀inlammatory฀macrophages฀and฀transforming฀growth฀ factor-beta฀isoforms.฀Wound Repair Regen.฀1994;2:104–112. 17.฀ Lorenz฀HP,฀Lin฀RY,฀Longaker฀MT,฀Whitby฀DJ,฀Adzick฀NS.฀The฀ fetal฀ibroblast:฀The฀effector฀cell฀of฀scarless฀fetal฀skin฀repair.฀ Plast Reconstr Surg.฀1995;96:1251–1259;฀discussion฀1260. 18.฀ West฀ DC,฀ Shaw฀ DM,฀ Lorenz฀ P,฀ Adzick฀ NS,฀ Longaker฀ MT.฀ Fibrotic฀healing฀of฀adult฀and฀late฀gestation฀fetal฀wounds฀cor- relates฀with฀increased฀hyaluronidase฀activity฀and฀removal฀of฀ hyaluronan.฀Int J Biochem Cell Biol.฀1997;29:201–210. 19.฀ Cass฀DL,฀Bullard฀KM,฀Sylvester฀KG,฀Yang฀EY,฀Longaker฀MT,฀ Adzick฀ NS.฀ Wound฀ size฀ and฀ gestational฀ age฀ modulate฀ scar฀ formation฀ in฀ fetal฀ wound฀ repair.฀ J Pediatr Surg.฀ 1997;32: 411–415. 20.฀ Mackool฀RJ,฀Gittes฀GK,฀Longaker฀MT.฀Scarless฀healing:฀The฀ fetal฀wound.฀Clin Plast Surg.฀1998;25:357–365. 21.฀Larson฀ BJ,฀ Longaker฀ MT,฀ Lorenz฀ HP.฀ Scarless฀ fetal฀ wound฀ healing:฀ A฀ basic฀ science฀ review.฀ Plast Reconstr Surg.฀ 2010;126:1172–1180. 22.฀ Werner฀ S,฀ Smola฀ H,฀ Liao฀ X,฀ et฀ al.฀ The฀ function฀ of฀ KGF฀ in฀ morphogenesis฀ of฀ epithelium฀ and฀ reepithelialization฀ of฀ wounds.฀Science฀1994;266:819–822. 23.฀ Wong฀VW,฀Rustad฀KC,฀Akaishi฀S,฀et฀al.฀Focal฀adhesion฀kinase฀ links฀mechanical฀force฀to฀skin฀ ibrosis฀via฀inlammatory฀sig- naling.฀Nat Med.฀2012;18:148–152. 24.฀ Wong฀ VW,฀ Akaishi฀ S,฀ Longaker฀ MT,฀ Gurtner฀ GC.฀ Pushing฀ back:฀Wound฀mechanotransduction฀in฀repair฀and฀regenera- tion.฀J Invest Dermatol.฀2011;131:2186–2196. 25.฀ Aarabi฀ S,฀ Longaker฀ MT,฀ Gurtner฀ GC.฀ Hypertrophic฀ scar฀ formation฀following฀burns฀and฀trauma:฀New฀approaches฀to฀ treatment.฀PLoS Med.฀2007;4:e234. 26.฀ Wong฀VW,฀Paterno฀J,฀Sorkin฀M,฀et฀al.฀Mechanical฀force฀pro- longs฀acute฀inlammation฀via฀T-cell-dependent฀pathways฀dur- ing฀scar฀formation.฀FASEB J.฀2011;25:4498–4510. 27.฀ Aarabi฀ S,฀ Bhatt฀ KA,฀ Shi฀ Y,฀ et฀ al.฀ Mechanical฀ load฀ initiates฀ hypertrophic฀ scar฀ formation฀ through฀ decreased฀ cellular฀ apoptosis.฀FASEB J.฀2007;21:3250–3261. 28.฀Wang฀Z,฀Fong฀KD,฀Phan฀TT,฀Lim฀IJ,฀Longaker฀MT,฀Yang฀GP.฀ Increased฀ transcriptional฀ response฀ to฀ mechanical฀ strain฀ in฀ keloid฀ ibroblasts฀due฀to฀ increased฀focal฀adhesion฀complex฀ formation.฀J Cell Physiol.฀2006;206:510–517. 29.฀ Wong฀VW,฀Longaker฀MT,฀Gurtner฀GC.฀Soft฀tissue฀mechano- transduction฀ in฀ wound฀ healing฀ and฀ ibrosis.฀ Semin Cell Dev Biol.฀2012;23:981–986. 30.฀ Gurtner฀GC,฀Werner฀S,฀Barrandon฀Y,฀Longaker฀MT.฀Wound฀ repair฀and฀regeneration.฀Nature฀2008;453:314–321. 31.฀ Gurtner฀ GC,฀ Dauskardt฀ RH,฀ Wong฀ VW,฀ et฀ al.฀ Improving฀ cutaneous฀ scar฀ formation฀ by฀ controlling฀ the฀ mechanical฀ environment:฀ Large฀ animal฀ and฀ phase฀ I฀ studies.฀ Ann Surg.฀ 2011;254:217–225. 32.฀ Lim฀AF,฀Weintraub฀J,฀Kaplan฀EN,฀et฀al.฀The฀embrace฀device฀ signiicantly฀ decreases฀ scarring฀ following฀ scar฀ revision฀ sur- gery฀ in฀ a฀ randomized฀ controlled฀ trial.฀ Plast Reconstr Surg.฀ 2014;133:398–405. 33.฀ Longaker฀MT,฀Rohrich฀RJ,฀Greenberg฀L,฀et฀al.฀A฀randomized฀ controlled฀ trial฀ of฀ the฀ embrace฀ device฀ to฀ reduce฀ incisional฀ scar฀formation.฀Plast Reconstr Surg.฀Accepted฀for฀publication. Factors Influencing Fellowship Selection, Career Trajectory, and Academic Productivity among Plastic Surgeons Sir: I read฀with฀great฀interest฀the฀article฀written฀by฀DeLong฀ et฀ al. 1 ฀ and฀ the฀ corresponding฀ Discussion฀ written฀ by฀ Greives฀and฀Losee 2 ฀that฀describes฀the฀factors฀that฀inlu- ence฀academic฀productivity฀among฀plastic฀surgeons.฀As฀ a฀budding฀plastic฀surgeon,฀their฀reports฀have฀prompted฀ me฀and฀probably฀many฀other฀students฀like฀me฀to฀con- template฀our฀future฀in฀this฀ield;฀I฀therefore฀commend฀ the฀ authors฀ for฀ this฀ and฀ for฀ their฀ well-versed฀ insights.฀ However,฀the฀commentaries฀given฀by฀the฀two฀groups฀of฀ authors฀raise฀a฀few฀questions. One฀of฀the฀conclusions฀reported฀by฀DeLong฀et฀al.฀ is฀ that฀ a฀ higher฀ number฀ of฀ publications,฀ in฀ addition฀ to฀ strong฀ mentor฀ relations,฀ correlated฀ with฀ a฀ future฀ career฀in฀academia. 1 ฀Greives฀and฀Losee฀seem฀to฀agree฀ but฀ have฀ the฀ opinion฀ that฀ those฀ who฀ pursue฀ a฀ career฀ in฀academia฀are฀“early฀differentiators.” 2 ฀By฀extension,฀ this฀suggests฀that฀the฀7-year฀integrated฀plastic฀surgery฀ programs,฀encompassing฀a฀mandatory฀year฀of฀research,฀ may฀ not฀ be฀ a฀ successful฀ means฀ of฀ fostering฀ the฀ next฀ breed฀ of฀ academic฀ “hardcores,”฀ unless฀ they฀ have฀ already฀differentiated฀before฀this.฀Would฀this฀assump- tion฀be฀correct? Moreover,฀ it฀ would฀ have฀ been฀ interesting฀ to฀ see฀ whether,฀speciically,฀irst-author฀publications฀correlated฀ with฀a฀career฀in฀academia.฀As฀Greives฀and฀Losee฀alluded฀ to,฀ many฀ medical฀ students฀ realize฀ that฀ taking฀ 1฀ year฀ out฀and฀striving฀to฀be฀included฀as฀an฀author฀in฀as฀many฀ publications฀ as฀ possible฀ is฀ their฀ “ticket฀ to฀ residency.” 2 However,฀it฀seems฀conceivable฀that฀the฀student฀who฀con- tributes฀relatively฀little฀to฀a฀number฀of฀projects฀and฀is฀a฀ named฀fourth฀or฀ifth฀author฀for฀multiple฀publications฀ may฀not฀fully฀embrace฀the฀academic฀trail฀as฀much฀as฀a฀ student฀ who฀ designed฀ and฀ drove฀ a฀ project฀ and฀ earned฀ a฀ irst-author฀ publication฀ as฀ a฀ result,฀ even฀ though฀ the฀ former฀ may฀ have฀ more฀ publications฀ overall.฀ In฀ the฀ United฀Kingdom,฀recruitment฀into฀plastic฀surgery฀train- ing฀ is฀ also฀ regarded฀ as฀ being฀ highly฀ competitive. 3 ฀ The฀ number฀of฀publications฀the฀candidate฀has฀forms฀part฀of฀ the฀ selection฀ criteria,฀ and฀ greater฀ merit฀ is฀ awarded฀ for฀ irst-author฀ publications. 3 ฀ Although฀ I฀ am฀ mindful฀ that฀ in฀ the฀ United฀ States฀ the฀ value฀ of฀ a฀ particular฀ publica- tion฀is฀determined฀on฀an฀institution-to-institution฀basis, 4 should฀ program฀ directors฀ at฀ academic-orientated฀ insti- tutions฀not฀aim฀for฀criteria฀similar฀to฀those฀in฀the฀United฀ Kingdom฀in฀vetting฀prospective฀residents? Similarly,฀ do฀ individuals฀ with฀ higher฀ degrees฀ before฀residency฀have฀an฀inclination฀toward฀academia?฀