International Medical Journal Vol. 19, No. 1, pp. 55 - 58 , March 2012 OPHTHALMOLOGY Vision-Related Quality of Life after Phacoemulsification with Akreos Adapt Advanced Optics and Tecnis ZA9003 Intraocular Lenses Rohana Abd-Rashid 1,2) , Gan Eng Hui 1) , Wan Hazabbah Wan Hitam 1) , Nik Azlan Zaid 2) , Ismail Shatriah 1) ABSTRACT Objective: To compare vision-related quality of life following phacoemulsification with 2 different aspheric lenses, Akreos Adapt Advanced Optics (AO) and Tecnis ZA9003 IOLs. Design: A randomised clinical trial. Material and Methods: 112 patients with significant age related cataract were recruited into this study. All patients had clear cornea phacoemulsification surgery, 61 patients (61 eyes) were implanted with aspheric Akreos Adapt AO IOL and 51 patients (51 eyes) were implanted with aspheric Tecnis ZA9003 IOL. Preoperatively, Early Treatment Diabetic Retinopathy Study (EDTRS) visual acuity was measured and mesopic pupil sizes were determined. At 3 months postoperatively, EDTRS visual acuity and contrast sensitivity with corrected refractory error using CSV 1000 chart was measured under photopic and mesopic lighting condition. Vision-related quality of life questionnaires based on VF-14 in Malay language was completed by each patient. Results: In 112 eyes evaluated, there was no statistically significant difference of pre and post operative visual acuity and post operative contrast sensitivity, both in photopic (p = 0.323) and mesopic (p = 0.604) between the two groups. Patients' satis- faction was parallel, the mean VF-14 scores in Akreos Adapt AO group was 98.57 (2.51) and Tecnis ZA9003 group was 97.18 (5.46) (p = 0.501). Conclusion: The best corrected visual acuity and contrast sensitivity in both photopic and mesopic were parallel in both groups. Patients who underwent phacoemulsification with Akreos Adapt AO and Tecnis ZA9003 implantation had comparable vision-related quality of life at 3 months postoperative period. KEY WORDS vision-related quality of life, after phacoemulsification, aspheric lenses Received on April 9, 2011 and accepted on July 11, 2011 1) Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia 16150 Kubang Kerian, Kelantan, Malaysia 2) Eye Clinic, Hospital Raja Perempuan Zainab II 15990 Kota Bharu, Kelantan, Malaysia Correspondence to: Ismail Shatriah (e-mail: shatriah@kck.usm.m) 55 INTRODUCTION Gain of visual function and quality of life after cataract surgery had been studied and showed significant improvement 1-7) . The emer- gence of aspheric lens had created a new evolution in the design of intraocular lens (IOL) to compensate the positive corneal spherical aberration. Few studies had reported that improvement in contrast sensitivity with the aspheric IOL compared to conventional IOL 8-12) . Akreos Adapt AO is an acrylic intraocular lens with anterior and posterior aspheric surface. It has zero spherical aberration. Tecnis ZA9003 is also an acrylic intraocular lens with a modified prolate anterior surface design, which has a negative spherical aberration compensates with the positive aberration of the cornea. These designs developed to minimize the total amount of ocular spherical aberration and improve visual function post cataract surgery 13) . In the present era, the advances in cataract surgery and IOL tech- nology provides better quality of vision, which ultimately will pro- mote increase in quality of life. Increasing investigation in impaired vision and contrast sensitivity will be of great benefit to the world- wide society. Our aim is to compare the visual acuity, contrast sensi- tivity and vision-related quality of life following phacoemulsification with 2 different aspheric IOLs implantation that are commonly used in clinical practice, i.e. Akreos Adapt AO and Tecnis ZA9003 IOLs. MATERIALS AND METHODS We conducted a randomized clinical trial with parallel 2 arms, double blinded study in 2 tertiary hospitals in Malaysia, i.e. Hospital Universiti Sains Malaysia, Kelantan, Malaysia and Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia. A non-proba- bility sampling with block randomization schedule was prepared with the IOL group in blocks of four. The study protocol was approved by the Research and Ethical Committee, School of Medical Sciences, Universiti Sains Malaysia, and written consents were obtained from all the patients. Sample size was calculated using two means (independent observation) formula with z α= 1.96,α= 0.05 and 80% power. The inclusion criteria were patients with age-related cataract and requiring IOL power between 15-25 D. Patients with pre-existing ocu- lar condition affecting the visual acuity, contrast sensitivity and central vision, dilated pupil smaller than 4.0 mm, previous intraocular surgery or ocular trauma that causes injury to optic nerves were excluded. Patients with complicated cataract surgery, postoperative induced C 2012 Japan International Cultural Exchange Foundation & Japan Health Sciences University