Reduan et al. 2016 Health and the Environment Journal, 2016, Vol. 7 No. 1 pp 43-58 43 Determination of Dose in HDR Brachytherapy by using Treatment Planning System, Manual Calculation and Film Measurement Reduan Abdullah*, Adibah Hanim Ahmad and Chen Suk Chiang School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia *Corresponding author: reduan@usm.my ABSTRACT: The performance of treatment planning system (TPS) nowadays is a key component in order to deliver an accurate treatment towards target volume in any radiation therapy process. Thus, the purpose of this study is to verify the point doses calculated by Oncentra Brachytherapy Treatment Planning Software 4.1 (Nucletron, Netherlands). Three different simple geometric catheter configurations were planned in TPS, and point doses of TPS calculation were compared with manual calculation and measured point doses using Gafchromic EBT2 films. For manual calculation of three simple geometric catheter configurations planned, 68% of calculated dose agreed with TPS calculation within 10%. This is because the TPS and manual calculations are based on the similar AAPM TG-43 formalism. Meanwhile, 11% of the measured point doses agreed with the TPS calculation within 10%. The films had high spatial resolution, which was highly sensitive for measuring doses in high dose gradient but it also led to overestimation of the dose. It was also inaccurate in detecting the lower dose region due to energy dependence. In conclusion, manually calculated point doses gave the most reliable point dose results compared to the measured point doses in this study. The method used in this study can be used as a procedure for evaluating the accuracy of calculated point doses prior installing and commissioning a new TPS. Keywords: AAPM TG-43 formalism, brachytherapy treatment planning system, point doses measurements