Dinesh et. al. /International Journal of Modern Sciences and Engineering Technology (IJMSET) ISSN 2349-3755; Available at https://www.ijmset.com Volume 2, Issue 1, 2015, pp.23-30 © IJMSET-Advanced Scientific Research Forum (ASRF), All Rights Reserved “IJMSET promotes research nature, Research nature enriches the world’s future” 23 Injection Placentrex in the Management of Oral Submucous Fibrosis Abstract Oral submucous fibrosis, an incidious chronic precancerous condition of oral cavity mainly occurs in Indian sub continent. The incidence varies from 0.2 to 0.5% in India with higher percentage in our place (Hyderabad) due to increased habits of chewing gutka, eating chilies and hard roti. The exact etiology is still obscure, but many factors have been thought. It manifests as, burning sensation and inability to eat. Various agents have been tried in treatment but none is promising. In the present prospective study, an attempt has been made to study the effect of placenta extract in the management of oral submucous fibrosis with no significant side effects. It has no contra indications and can be used in early stages of oral submucous fibrosis with good results and effect is long standing. Keywords: Placenta extract, oral submucous fibrosis, management. 1. INTRODUCTION: Many people are subjected to stress and tension in this century. Most of them fall into the tension relieving habits like smoking, alcoholism, pan tobacco or betel nut chewing. These habits not only relieve tension to some extent but also produce bad effects on human body apart from being addictive. Oral submucous fibrosis (OSMF) is one of the conditions resulting from these tensions relieving habits. Oral submucous fibrosis has been well-established in Indian medical literature since the time of Sushruta. In the modern literature it was first described by Schwartz. In India. Joshi (1953) was the first to describe the condition and he called the condition “submucous fibrosis of the palate and pillars (Moss et al. 1968). Oral submucous fibrosis is an insidious chronic disease of unknown etiology affecting the mucosa of any part of the oral cavity and occasionally extending to pharynx and oesophagous and rarely to larynx. The condition is sometimes associated with juxt a inflammatory reaction followed by a fibro elastic change of the lamina propria with epithelial atropy leading to stiffness of the oral mucosa causing trismus and inability to eat (Pindborg et al. 1972) OSMF is a silent ailment which is on rise in the younger age group the disease is more prevalent in india and more in our part (Hyderabad-Karnataka). The prevalence rate (Ramanjaneyulu et al. 1980) varies from 0.2 to 0.5 % in India with a higher percentage being found in the southern areas of the country. Large number of cases occurs between the age of 20 and 40 years (Simposum et al. 1968). Various etiological factors have been suggested like betel nut chewing, high chilly intake, malnutrition, Vitamin imbalance, autoimmunity and genetic predisposition (Daftary et al. 1992; Kacker 1975). But the exact etiology of oral submucous fibrosis has not been established till today. The pathogenesis of oral submucous fibrosis lies in the continuous action of mild irritants. Many studies has suggested that oral submucous fibrosis is a precancerous condition and it was first mentioned by Pay master J.C. in 1956 (Daftary et al. 1992).The close association between betel nut Dr. T. Dinesh Singh 1 Department of ENT, OHRC, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, India Dr. Sudhir Padshetty 2 MNR Medical College Sangareddy, Hyderabad, India Sara Shreen 3 Teegala Krishna Reddy College of Pharmacy, Meerpet, Hyderabad, India Nazima Begum 4 CLRD, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, India Sandeep K Vishwakarma 4 CLRD, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, India *Dr. Aleem A Khan 4 CLRD, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, India aleem_a_khan@rediffmail.com