6–9 October 2013, Sydney, Australia Oral communication abstracts receptivity, when performed during oral contraceptive pills (OCP) pre-treatment, in unselected women undergoing assisted reproductive techniques (ART). Methods: Women undergoing ART were randomly allocated to perform either endometrial injury with a pipelle de Cornier or a sham procedure, 14–7 days before starting controlled ovarian stimulation (COS). We evaluated clinical pregnancy, live birth (both per women allocated), miscarriage, multiple pregnancy (both per clinical pregnancy), and implantation rate. Pain during procedure was evaluated using a 10cm visual analogue scale. Endometrial thickness and volume, and the three-dimensional power Doppler (3DPD) indices (VI, FI and VFI) were assessed during COS when at least one follicle was ≥17mm. Results: 79 women were included in each group. Endometrial injury increased live birth (41.8% vs. 22.8%, injury vs. control respectively; P = 0.01), clinical pregnancy (49.4% vs. 29.1%; P = 0.01), implantation rate (35.8% vs. 21.3%; P=0.01), pain (6.42 ± 2.35 cm vs. 1.82 ± 1.52 cm; P<0.001), endometrial VI (3.71±1.77 vs. 2.95±1.56; P<0.01), and VFI (0.97±0.51 vs. 0.76 ± 0.40; P < 0.01). No significant effect was observed on miscarriage (15.4% vs. 21.7%, P = 0.53) and multiple pregnancy (22.5% vs. 25.0%, P = 0.79), endometrial thickness (10.12±1.55mm vs. 9.98 ± 1.62 mm; P = 0.59), volume (6.18 ± 1.63 cc vs. 6.01 ± 1.48 cc; P = 0.51), and FI (26.12 ± 2.82 vs. 25.91 ± 2.72; P = 0.65). Conclusions: Endometrial injury performed only once, under OCP pre-treatment, in the month before initiation of COS for ART, increased live birth, clinical pregnancy, and implantation rates without evidence of effect on miscarriage and multiple pregnancy. The intervention also changed some markers of 3DPD markers of endometrial receptivity but causes a considerable pain. OC11.02 Three-dimensional ultrasound in diagnosis of congenital uterine anomalies comparing with magnetic resonance imaging B. Graupera, M. Pascual, L. Hereter, B. ´ Ubeda, C. Pedrero, M. Fern ´ andez-Cid Obstetrics, Gynecology and Reproduction, Institut Universitari Dexeus, Barcelona, Spain Objectives: The purpose of this study was to evaluate the accuracy of three-dimensional transvaginal ultrasound (3DUS) in the diagnosis of septate, arcuate and unicornuate uteri compared with magnetic resonance imaging (MRI) as the gold standard. Methods: In this prospective study 60 women diagnosed with uterine anomalies were evaluated by 3DUS and MRI. Stored 3D volumes were then examined using render mode. We classified a uterus as a septate when the cavity was completely or partially divided by a septum, as a arcuate if there are a concave fundal cavity indentation and as a unicornuate if there are a single cavity showing an abnormal lenticular shape. The sensitivity, specificity, and positive (PPV) and negative (NPV) predictive values of 3DUS were calculated using MRI as the gold standard. Results: A septate uterus was sonographically diagnosed in 18 (30%) women, arcuate uterus in 29 (48%), unicornuate uterus in 5 (8%), and 8 (14%) women with other diagnoses out of the 60 women included in the study group. The MRI revealed a septate uterus in 17 (28%) cases and arcuate uterus in 25 (42%) cases. All patients sonographically diagnosed with unicornuate uterus were confirmed by MRI. In one case a septate uterus was diagnosed by 3DUS, while one bicornuate uterus was revealed by MRI. In 4 cases where arcuate uterus was diagnosed by 3DUS, MRI revealed normal morphology. 3DUS demonstrated sensitivity, specificity, PPV and NPV of 100%, 97.67%, 94.44% and 100% respectively in the ∗ This presentation is eligible for the Young Investigator award (to be presented in the closing session). diagnosis of septate uteri; 100%, 88.57%, 86.21% and 100% respectively in the diagnosis of arcuate uteri. Sensitivity, specificity, PPV and NPV in the diagnosis of unicornuate uteri was 100%. The Kappa value between both methods was 0.96, 0.86 and 1 in the diagnosis of septate, arcuate and unicornuate uteri. Conclusions: 3DUS is an accurate method for the diagnosis of uterine malformations, especially in septate, arcuate and unicornuate uteri with a very good agreement with the MRI results. OC11.03 *Fetal cardiovascular dysfunction is present in pregnancies conceived by assisted reproductive technologies B. Valenzuela-Alcaraz 1 , F. Crispi 1,2 , B. Bijnens 3 , M. Cruz Lemini 1 , M. Creus 1 , M. Sitges 4 , S. C ´ Ivico 1 , J. Balasch 1 , E. Gratac ´ os 1,2 1 Institut Cl ´ ınic de Ginecologia, Obstetr ´ ıcia i Neonatologia, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain; 2 Centro de Investigaci ´ on Biom´ edica en Red en Enfermedades Raras, Barcelona, Spain; 3 Instituci ´ o Catalana de Recerca i Estudis Avanc ¸ats (ICREA), Universitat Pompeu Fabra, Barcelona, Spain; 4 Cardiology Department, Thorax Institute, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain Objectives: Children conceived by assisted reproductive technolo- gies (ART) show postnatal hypertension and vascular dysfunction. Our aim was to evaluate cardiac and vascular function in fetuses and neonates conceived by ART. Methods: A prospective cohort study included 70 fetuses conceived by ART and 70 controls spontaneously conceived. Fetal echocardio- graphy was performed at 28 weeks of gestation including cardiac morphometry, longitudinal motion by M-mode (TAPSE), tissue Doppler (mitral early diastolic annular peak velocity, E’). Neona- tal evaluation included blood pressure and aortic intima-media wall thickness measurements. Results were calculated by linear regression adjusted by birthweight and pre-eclampsia. Results: ART fetuses had similar estimated fetal weight at scan. Signs of cardiac remodeling included dilated atria (right atrium/heart ratio CTRL 1.45 vs. ART 1.6%), more globular hearts (right sphericity index in CTRL 1.6 vs. ART 1.4), thicker myocardial walls (septal wall thickness in CTRL 2.4 vs. ART 2.8 mm), decreased longitudinal systolic function (TAPSE in CTRL 6.5 vs. ART 5.5 mm) and impaired relaxation (mitral E’ in CTRL 8.4 vs. ART 8 cm/s). ART neonates showed a tendency to higher mean blood pressure (CTRL 63 vs. ART 67 mmHg) and aortic wall thickness (CTRL 0.46 vs. ART 0.55 mm). Conclusions: ART is associated with both cardiac and vascular remodeling already present in fetal life. This opens opportunities for early detection and potential intervention in these children. OC11.03: Table 1. Controls ART P-value Cerebroplacental ratio 1.9 (1.8-2.0) 2.0 (1.8-1.9) 0.784 Right atrium/heart ratio (%) 1.45 (1.26-1.58) 1.6 (1.27-1.82) 0.011 Right sphericity index 1.6 (1.42-1.73) 1.4 (1.28-1.55) <0.001 Interventricular septum thickness 2.4 (2.2-2.7) 2.8 (2.4-3) 0.001 Tricuspid ring displacement (mm) 6.5 (6–7.1) 5.5 (5.1-6.1) <0.001 Mitral E’ (cm/s) 8.4 (7.9-9.3) 8 (7–11) 0.002 Aortic mean IMT (mm) 0.46 (0.35-0.52) 0.55 (0.52-0.60) 0.016 Data are presented as Mean ± SD. Ultrasound in Obstetrics & Gynecology 2013; 42 (Suppl. 1): 1–47. 21