________________________________________ * Author for correspondence; E-mail: shritupare@yahoo.com Int. J. Chem. Sci.: 10(4), 2012, 1837-1843 ISSN 0972-768X www.sadgurupublications.com FACILE AND EFFICIENT METHOD FOR PREPARATION OF SCHIFF BASES CATALYZED BY Ni (NO 3 ) 2 .6H 2 O UNDER ROOM TEMPERATURE SHRIKRISHNA D. TUPARE, DINESH V. BHAGAT, SATISH A. DAKE a and RAJENDRA P. PAWAR * Department of Chemistry, K. E. S. Anandibai Pradhan Science College, NAGOTHANE, Raigad (M.S.) INDIA a Department of Chemistry, Deogiri College, AURANGABAD (M.S.) INDIA ABSTRACT The important and interesting roles of Schiff bases are an intermediate in the biologically important transmutation reaction. Heterocyclic Schiff bases have been reported as antibacterial and antifungal activities. They were synthesized by different methods by the condensation between primary amines and aldehyde or ketones. From literature survey, it was cleared that many work on Schiff bases is going on. But each work is only concerns with conventional method and grinding method. But very few reports were observed on synthesis of Schiff bases by green approach. Therefore, in present work some Schiff bases were prepared with help of aromatic primary amines and highly substituted aromatic aldehydes in methanol and in presence of Ni (NO 3 ) 2 .6H 2 O as catalyst at room temperature. Key words: Schiff bases, Aldehyde, Ketones, Biological activity, Catalyst. INTRODUCTION Schiff bases derived from aromatic amines and aromatic aldedydes are a very important class of organic compounds because of their applications in many fields, including biological 1-9 , inorganic 10-14 and analytical chemistry 15-19 . The chemistry of the carbon- nitrogen double bond plays a vital role in the progresses of chemistry science 20 . Schiff-base compounds have been used as fine chemicals and medical substrates. Recently multi-dentate complexes of iron and nickel showed high activities of ethylene oligomerization and polymerization. Studies on the bioavailability of heterocyclic Schiff bases from natural sources are limited, but synthetic heterocyclic Schiff bases have been reported to have a wide range of biological properties, especially antibacterial 4,21,22 and antifungal activities 5 .