labeling, and dressing and tubing change requirements and techniques. RESULTS: After the rollout of the toolkit in May 2013, we have seen zero CLABSIs each month through November 2013. Getting our nurses “back to basics” when it comes to line care was not easy at first, but the numbers speak for themselves. LESSON LEARNED: Sometimes infection control technology, although helpful, can mask clinical practice problems. When our health system discontinued swab caps, we found an opportunity to improve our nursing practice and decreased CLABSIs with basic line care. Publication Number 418 Significant Improvement in CLABSI Rates Following Routine Use of Disinfection Caps on All Access Ports: Better Safety, Better Resource Utilization Marcelina M. Wawrzyniak MSN, RN, Infection Preventionist, Loyola University Medical Center; Jorge Parada MD, MPH, Medical Director, Infection Prevention and Control, Loyola University Medical Center; Keeley Lewis MPH, Public Health Researcher, Loyola University Chicago; Ashley Mallek BSHSM, Data Analysist, Loyola University Medical Center; Sylvia Suarez-Ponce BSN, RN, Infection Practitioner, Loyola University Medical Center; Elaine Trulis MS, BSN, RN, Infection Practitioner, Loyola University Medical Center; Herminia Pua BSN, RN, Infection Practitioner, Loyola University Medical Center; Alexander Tomich RN, MSN, DPN, Director, Infection Control, Rush Unversity Medical Center BACKGROUND/OBJECTIVES: One source of central line associated blood stream infections (CLABSIs) are device contamination by microorganisms spreading from the extraluminal surface to the intraluminal surface from the catheter hub access port(s). If ports were better disinfected before and after each use, and protected from surface contamination, CLABSI rates should fall. The routine use of sterile, single-use disinfecting devices containing isopropyl alcohol (IPA) that attach to IV access ports may aid in decreasing CLABSIs. METHODS: This single center 2-year pre-post observational study examined CLABSI rates for a 12-month baseline standard care vs. a 12-month period when the use of IPA impregnated disinfection caps on all central line access ports became standard practice hospital-wide. CLABSI rates were tracked for all adult ICUs, non- ICUs, and pediatric units. Two ICUs were dropped from the analysis (Burn ICU and Coronary Care/Heart Transplant Unit), because they had served as the pilot units for an earlier disinfection device study that overlapped this study. Findings were then extrapolated to determine potential impact of a full year of IPA impregnated cap use. RESULTS: During the 2-year study we noted a 68% decrease in the overall number of CLABSIs with 59 CLABSIs during the 12-month standard care period vs 23 CLABSIs during the 12-month inter- vention period (1.95 vs 0.62/1000 central line days (CLDs), p<0.001). Adult ICU CLABSIs decreased 55% (22 vs 11 CLABSIs,1.74 vs 0.79/1000 CLDs, p¼0.039). Non-ICU floor units CLABSIs de- creases 74% (26 vs 10 CLABSIs, 2.14 vs 0.55/1000 CLDs, p<0.001) (see Figures). Pediatric units also had substantially decreased CLABSIs. Altogether, we observed 36 fewer CLABSIs during the year- long intervention period than would have been expected had usual care continued. CONCLUSIONS: We observed an immediate, widespread and sub- stantial reduction in CLABSI rates throughout our medical center after the introduction of routine use of disinfection devices on all central line access ports. 36 fewer CLABSIs were observed in the 12- month post-intervention period than would have been expected had usual standard care continued. Using CDC estimates of Oral Abstracts / American Journal of Infection Control 42 (2014) S3-S28 S15 APIC 41st Annual Educational Conference & International Meeting j Anaheim, CA j June 7-9, 2014