Mediterr J Hematol Infect Dis 2011; 3; Open Journal S MEDITERRANEAN J Case Report Therapy Outcome of a T-Ce CHOP in Ibadan, Nigeria: a C Olaniyi J.A 1 , Oluwasola A.O. 2 and Ibij 1 Department of Haematology and 2 Hist Correspondence to: Olaniyi J.A. E-mail: Competing interests: The authors have Published: March 16, 2011 Received: November 11, 2010 Accepted: January 29, 2011 Mediterr J Hematol Infect Dis 2011, 3: e20 This article is available from: http://www.m This is an Open Access article dist (http://creativecommons.org/licenses/by/2.0 provided the original work is properly cited T-cell-rich B-cell lymphoma (TCR characterized by few neoplastic B nodular lymphocyte predominant A case of a 46 year old man refe weight loss, low grade pyrexia an TCRBCL is described. The clinical course was indeed ag CHOP combination chemothera growth/infiltration were frequent and eventually became overwhelm This case, being the first case of managed at this centre with R-CH clinical challenges faced and ritux also serve to increase our index o diagnosis of lymphoma. Introduction: T-cell Rich B-Ce (TCRBCL), previously considered extrapulmonary form of Granulomatosus. It is generally consid cell lymphoma with an exuberant reaction. 1,2 It was first desc clinicopathological entity in 1972. 3 I based on histological triad of: polymo infiltrate composed of small lymphocyt and variable number of large atypic cells; angitis due to transmural infiltra System JOURNAL OF HEMATOLOGY AND INFE www.mjhid.org ISSN 2035-3006 ell-Rich-B-Cell Lymphoma (TCRBC Case Report. jola A 1 topathology, University College Hospital, Ibadan, : ayodeleolaniyi8@gmail.com e declared that no competing interests exist. 011008, DOI 10.4084/MJHID.2011.008 mjhid.org/article/view/7077 tributed under the terms of the Creative Co 0 ), which permits unrestricted use, distribution, and d. RBCL) is considered a rare variant of aggr B cells and a large reactive infiltrate with t Hodgkin’s lymphoma. erred with a 5 months history of general nd two separately reported lymph node h ggressive because in spite of initial treatm apy, followed by R+CHOP(x 6 cycles) tly observed. Also, recurrent infection was ming resulting to the loss of the patient. TCRBCL diagnosed by immunohistochem HOP, is presented to highlight the dilemm ximab therapy outcome especially in resour of suspicion and the need reinforce immu ell Lymphoma d to be an Lymphomatous dered to be a B benign T cell cribed as a It’s diagnosis is orphic lymphoid tes, plasma cells cal mononuclear ation of arteries and veins by lymphocytes from vasculitis in whi inflammatory cells are foun necrosis) and granulomatos the lymphoid nodules and n Therefore, by 1990, the d extranodal, angiocentric, predilection for the lungs. 5 Flow cytometric im polymerase chain reactio receptor and immunoglobul ECTIOUS DISEASES CL) Patient with R- , Nigeria ommons Attribution License reproduction in any medium, ressive B cell lymphoma h striking similarities to lized lymphadenopathy, histology consistent with ment with four cycles of ), signs of tumor re- s frequent, troublesome mical confirmation and ma in making diagnosis, rce poor country. It will unohistochemistry in the (a process quite different ich acute and chronic nd with associated cell wall sis (central necrosis within not granuloma formation). 4 disease was viewed as an T cell lymphoma with mmunophenotyping and on that determine T-cell lin clonality is the hallmark