www.rsc.org/chemcomm Registered Charity Number 207890 As featured in: See Kana M. Sureshan et al., Chem. Commun., 2013, 49, 1494. Showcasing research from Prof. Kana M. Sureshan’s Laboratory, Indian Institute of Science Education and Research, Thiruvananthapuram (IISER-TVM), Kerala, India Supramolecular design of a bicomponent topochemical reaction between two non-identical molecules The irst design and execution of a topochemical reaction between two non-identical reactants using supramolecular chemistry approach is reported. A coassembly of two sugar-based organogelators with complimentary reacting motifs, viz azide and alkyne, undergoes topochemical Huisgen reaction between them.