An Evidence-Based Systematic Review of Umckaloabo (Pelargonium sidoides) by the Natural Standard Research Collaboration Catherine Ulbricht, PharmD Tracee Rae Abrams, PharmD Julie Conquer, PhD Dawn Costa, BA, BS Jill M Grimes Serrano, PhD Ramon Iovin, PhD Richard Isaac Yen Nguyen, PharmD Erica Rusie, PharmD Diem Tran, PharmD Wendy Weissner, BA Regina C. Windsor, MPH ABSTRACT. An evidence-based systematic review, including written and statistical analysis of scientiﬁc literature, expert opinion, folkloric precedent, history, pharma- cology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. KEYWORDS. Adverse effects, umckaloabo (Pelargonium sidoides), dosing, evidence-based, interactions, pharmacodynamics, pharmacology, pharmacokinetics, systematic review Catherine Ulbricht is afﬁliated with the Massachusetts General Hospital. Tracee Rae Abrams is afﬁliated with the University of Rhode Island. Julie Conquer is afﬁliated with the RGB Consulting. Dawn Costa is afﬁliated with the Natural Standard Research Collaboration. Jill M. Grimes Serrano is afﬁliated with the Natural Standard Research Collaboration. Ramon Iovin is afﬁliated with the Natural Standard Research Collaboration. Richard Isaac is afﬁliated with the Natural Standard Research Collaboration. Yen Nguyen is afﬁliated with the Massachusetts College of Pharmacy. Erica Rusie is afﬁliated with the Natural Standard Research Collaboration. Diem Tran is afﬁliated with the Massachusetts College of Pharmacy. Wendy Weissner is afﬁliated with the Natural Standard Research Collaboration. Regina C. Windsor is afﬁliated with the Natural Standard Research Collaboration. Address correspondence to: Catherine Ulbricht, PharmD, Massachusetts General Hospital E-mail: ulbricht@naturalstandard.com. Journal of Dietary Supplements, Vol. 7(3), 2010 Available online at www.informaworld.com/WJDS C  2010 by Informa Healthcare USA, Inc. All rights reserved. doi: 10.3109/19390211.2010.507116 283