3 Ecdysteroid Receptors and their Applications in Agriculture and Medicine Subba R. Palli,* Robert E. Hormann, { Uwe Schlattner, { and Markus Lezzi { *Department of Entomology, College of Agriculture, University of Kentucky Lexington, Kentucky 40546 { RheoGene Inc., Norristown, Pennsylvania 19403 { Institute of Cell Biology, Swiss Federal Institute of Technology (ETH), CH‐8093 Zurich, Switzerland I. Introduction II. Ecdysteroid Receptors A. Cellular Locale B. Construction of Ligand‐Controlled Transcription Factors C. Ligand‐Binding Domain D. DNA Binding Domain and Hinge Region E. N‐ and C‐Terminal Modulator Domains F. Sequence of Events III. Applications A. Medicine B. Agriculture IV. Conclusions and Perspectives References Vitamins and Hormones, Volume 73 0083-6729/05 $35.00 Copyright 2005, Elsevier Inc. All rights reserved. DOI: 10.1016/S0083-6729(05)73003-X 59