Professional Med J 2015;22(7):896-903. www.theprofesional.com ALCOHOLIC LIVER DISEASE (ALD) 896 The Professional Medical Journal www.theprofesional.com ALCOHOLIC LIVER DISEASE (ALD); IMPLICATION OF OXIDATIVE STRESS & EXTRAPOLATIVE FACTORS IN PATIENTS SUFFERING, UPDATE FROM LOCAL POPULATION OF PUNJAB-PAKISTAN Dr. Muhammad Saeed Qureshi 1 , Dr. Rizwan Ahmad 2 , Dr. Razia Rizwan 3 , Dr. Arif Malik 4 , Abdul Manan 5 , Dr. Mahmood Husain Qazi 6 , Sumaira Shaheen 7 , ORIGINAL PROF-2782 ABSTRACT… Objective: The aim of the present study was to investigate the changes in biochemical parameters including lipid proile, liver and kidney proile as well as oxidative stress proile, particularly in patients suffering from alcoholic liver disease (ALD). Study design: Fifty chronic alcoholics admitted for treatment to the in-patient wards at Jinnah Hospital, Lahore- Pakistan. Chronic alcoholics with alcohol abuse for more than four to ive years, and with or without clinical complications, were included. Apparently twenty healthy individuals served as control. Period: 2012-2013. Materials and methods: Various circulating biochemical biomarkers including renal proile, hepatic and lipid proile were evaluated. Moreover, stress markers (MDA. SOD, GSH and catalase) were also investigated. Results: A very strong direct and indirect correlation of ALP was found with TB, MDA and GSH (r=.950**, r=.929** and r=- .967** respectively, P<0.01). MDA was observed having very strong indirect correlation with GSH and catalase (r=-.909** and r=-.777** respectively, P<0.01). Conclusion: All parameters in combinations may be useful indicator or may be good and reliable biochemical markers for identiication and determination of severity of alcoholic liver diseases (ALD). The damaging of hepatocytes due to the consumption of alcohol disturbs almost all types of biochemical coordination in the biological system. Key words: Alcoholic Liver Disease (ALD), Total Bilirubin, lipid peroxidation, MDA, ALT, AST, ALP 1. Azra Naheed Medical College, Superior University, Lahore, Pakistan 2. Independent Medical College, Faisalabad-Pakistan 3. Independent Medical College, Faisalabad-Pakistan 4. Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Pakistan 5. Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Pakistan 6. Centre for Research in Molecular Medicine (CRIMM), The University of Lahore, Lahore, Pakistan. 7. Centre for Research in Molecular Medicine (CRIMM), the University of Lahore, Lahore, Pakistan. Correspondence Address: Arif Malik (PhD) Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Pakistan. arifuaf@yahoo.com Article received on: 22/01/2015 Accepted for publication: 05/05/2015 Received after proof reading: 09/07/2015 Article Citation: Qureshi MS, Ahmad R, Rizwan R, Malik A, Manan A, Qazi MH, Shaheen S. Alcoholic Liver Disease (ALD): Implication of oxidative stress and extrapolative factors in patients suffering, update from local population of Punjab-Pakistan. Professional Med J 2015;22(7):896-903. INTRODUCTION The liver is one of the largest organs in the body, weighting 3.3 pounds. It has a distinctive property that liver cells can be regenerated themselves. Because of this, damage to the liver cells cannot appear until or unless the damage caused is considerable and extensive. 1 It’s a very important organ in the body as its functions are very essential to life. Liver primarily ilters circulating blood and thus removing and destroying toxic substances. The major function of liver is to secrete bile in small intestine which helps in digestion and absorption of fats. The protein products manufactured as a result of metabolism are also converted by liver into urea so that they can be excreted via kidney. Liver also regulates blood clotting mechanisms. Because of the regenerative ability of liver this important organ can survive harsh condition during life time. 2 Hepatitis C is much considered as main cause for liver cirrhosis. Fat deposition in liver can be occurred in almost all heavy drinkers. This fatty liver can also be seen in nonalcoholic that drinks casually. Fatty liver is seemed to be reversible and this cannot leads towards serious disease. 1 Liver transplantation is one of the effective therapies available to some patient. 3 Liver cirrhosis is indolent disease, most of the patient show asymptomatic disease till the onset of last stage. 4 Liver cirrhosis is pathological disease that is characterized by irreversible chronic injury of hepatic cells in association of vast ibrosis. 5