www.wjpps.com 1802 Munendra et al. World Journal of Pharmacy and Pharmaceutical Sciences SYNTHESIS AND CHARACTERIZATION OF 5-(SUBSTITUTED PHENYL)- 2- FURFURALDEHYDES FROM SUBSTITUTED ANILINES *Munendra Mohan Varshney 1 , Asif Husain 2 , Versha Parcha 3 1 Faculty of pharmacy, Uttrakhand Technical University, post office chandanwadi, Prem Nagar, suddhowala, Dehradun-248007 (U.K), India 2 Dept. of pharmaceutical chemistry, Jamia Hamdard University, New Delhi, India 3 Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences, Dehradun (U.K), India ABSTRACT A new method for the synthesis of substituted furfuraldehyde is detailed. Reaction was carried out by substituted aniline to substituted diazonium chloride salt at 0 o C in the presence of sodium nitrite further Meerwin arylation reaction of diazonium chloride salt of substituted aniline with furfuraldehyde forms the different 5-( substituted phenyl)- 2-furfuraldehydes (IVa-k). The physical and spectral data of the synthesized compounds were obtained by melting point apparatus, IR, 1 H NMR spectroscopy. Keywords: Furfuraldehyde, Meerwin arylation, substituted anilines. INTRODUCTION The arylation of furfuraldehyde by the Meerwin method using various substituted anilines is the successful approach to forms the various furfuraldehyde derivatives [1-5]. These derivatives are using to synthesize newer Schiff bases with various substituted hydrazide derivatives [6]. Although furan ring containing heterocyclic compounds have also been exhibited to passage distinguish biological activities like antitumor [7], anti inflammatory [8], antimicrobial [9] and antiviral etc. all the synthesized compounds are subjected to physicochemical properties (Table 1) and spectral analysis (Table 2). WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Volume 2, Issue 4, 1802-1806. Research Article ISSN 2278 – 4357 Article Received on 10 May 2013, Revised on 1 June 2013, Accepted on 20 June 2013 *Correspondence for Author: * Munendra Mohan Varshney College of Pharmaceutical Sciences, Raj Kumar Goel Institute of Technology, Delhi Meerut Road, Ghaziabad (U.P), India. munendra_1978@rediffmail.co m