© 2016. Dinaol Belina , Yimer muktar, Birhanu Girma & Shimelis Mengistu. This is a research/review paper, distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License http://creativecommons.org/licenses/by- nc/3.0/), permitting all non commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Global Journal of Science Frontier Research: D Agriculture and Veterinary Volume 16 Issue 4 Version 1.0 Year 2016 Type : Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA) Online ISSN: 2249-4626 & Print ISSN: 0975-5896 Sero-Prevalence of Bovine Foot and Mouth Disease in Selected Districts of Eastern Showa Zone, Oromia Regional State, Ethiopia By Dinaol Belina , Yimer muktar, Birhanu Girma & Shimelis Mengistu Abstract- A cross-sectional study was conducted from September 2014 to July 2015 with the objective of determining sero-prevalence of Foot and Mouth Disease (FMD) in cattle in selected districts of Eastern Showa Zone, Oromia Regional. Blood samples were collected from a total of 634 cattle at Export abattoir, Veterinary Clinics in and around Bishoftu town of Adaa district and Bull screening quarantine station in Adama. The study animals were selected by systematic random sampling and blood samples were collected from jugular vein using sterile vacutainer tube. The blood samples were submitted to the National Veterinary Institute (NVI), and the serum were harvested and processed by using 3ABC-ELISA technique. The current study indicated the overall sero-prevalence of bovine FMD was 10.88% and statistically there were differences (P=0.002) in sero positivity of FMD among animals from Abattoir, Veterinary clinic and Feedlot. The sero-prevalence was higher in animals tested from export abattoirs than those from Feedlot and Clinics. Keywords: bovine, FMDV, sero-prevalence, ethiopia, 3ABC-ELISA. GJSFR-D Classification : FOR Code: 070706 SeroPrevalenceofBovineFootandMouthDiseaseinSelectedDistrictsofEasternShowaZoneOromiaRegionalStateEthiopia Strictly as per the compliance and regulations of : Haramaya University