Short report A bioactive biflavonoid from Campnosperma panamense B. Weniger a, * , C. Vonthron-Se ´ne ´cheau a , G.J. Arango b , M. Kaiser c , R. Brun c , R. Anton a a Laboratoire de Pharmacognosie, UMR N87081, Faculte ´ de Pharmacie, Universite ´ Louis Pasteur, BP 60024, 67401 Strasbourg, France b Facultad de Quı ´mica Farmace ´utica, Universidad de Antioquia, Apartado 1226, Medellı ´n, Colombia c Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland Received 18 June 2004; accepted 6 September 2004 Available online 27 October 2004 Abstract Lanaroflavone (1), a biflavonoid isolated from the methanol extract of the aerial part of Campnosperma panamense by bioguided fractionation, has been assessed for in vitro antiprotozoal activity. Lanaroflavone showed both antimalarial and leishmanicidal activities, but was inactive against Chagas disease vector, Trypanosoma cruzi . D 2004 Elsevier B.V. All rights reserved. Keywords: Campnosperma panamense; Lanaroflavone; Antiplasmodial activity; Leishmanicidal activity 1. Plant Campnosperma panamense Standl. (Anacardiaceae) leaves collected in May 2000 from Department del Valle, Colombia and identified by Dr. Robert T. Gonzalez, University del Valle. A voucher specimen (BW067) has been deposited in the Herbarium of the Universidad del Valle, Cali (CUVC). 0367-326X/$ - see front matter D 2004 Elsevier B.V. All rights reserved. doi:10.1016/j.fitote.2004.09.015 * Corresponding author. Tel.: +33 390 244238; fax: +33 390 244311. E-mail address: weniger@pharma.u-strasbg.fr (B. Weniger). Fitoterapia 75 (2004) 764 – 767 www.elsevier.com/locate/fitote