A. Elmanama, J. Al-Aqsa Unv., 10 (S.E.) 2006 59 Antimicrobial Resistance of Acinetobacter spp. Isolated from Pus Specimens from AL-Shifa Hospital, Gaza, Palestine. Dr. Abdelraouf A. Elmanama* ﺍﻟﻤﻠﺨﺹ ﺒﻐﺯﺓ ﺍﻟﺸﻔﺎﺀ ﻤﺴﺘﺸﻔﻰ ﻤﻥ ﺍﻟﺼﺩﻴﺩ ﻋﻴﻨﺎﺕ ﻤﻥ ﺍﻻﺴﻴﻨﻴﺘﻭﺒﺎﻜﺘﺭ ﻟﻌﺯﻻﺕ ﺍﻟﻤﻀﺎﺩﺍﺕ ﻤﻘﺎﻭﻤﺔ، ﻓﻠﺴﻁﻴﻥ ﺍﻻﺴ ﺒﻜﺘﻴﺭﻴﺎ ﺘﻌﺘﺒﺭ ﻤﻥ ﻤﺘﺯﺍﻴﺩ ﻋﺩﺩ ﻋﻥ ﻤﺴﺌﻭﻟﺔ ﻴﻨﻴﺘﻭﺒﺎﻜﺘﺭ ﺍﻻﻟﺘﻬﺎﺒﺎﺕ ﺍﻟﻤﺴﺘﺸﻔﻴﺎﺕ ﻓﻲ ﺍﻻﻨﺘﻬﺎﺯﻴﺔ. ﻭﺍﻜﺘﺴﺒ ﺕ ﺍﻟﺤﻴﻭﻴﺔ ﺍﻟﻤﻀﺎﺩﺍﺕ ﻤﻘﺎﻭﻤﺔ ﻋﻠﻰ ﻗﺩﺭﺘﻬﺎ ﺨﻼل ﻤﻥ ﻭﺍﺴﻌﺔ ﺸﻬﺭﺓ. ﺍﻟﺤﻴﻭﻴﺔ ﺍﻟﻤﻀﺎﺩﺍﺕ ﻤﻘﺎﻭﻤﺔ ﺩﺭﺍﺴﺎﺕ ﺘﻌﺘﺒﺭ ﻟﻤﺴﺎﻋﺩﺓ ﺍﻟﻌﺎﻟﻡ ﺒﻠﺩﺍﻥ ﻜل ﻓﻲ ﻤﻠﺤﺔ ﻀﺭﻭﺭﺓ ﺍﻷﻁﺒﺎﺀ ﺍﻟﻨﻅﺭﻴﺔ ﺍﻟﻌﻼﺠﺎﺕ ﻭﺼﻑ ﻓﻲ ﺍﻟﻤﺤﻠﻴﻴﻥ. ﻓـ ﺘﻡ ﻫـﺫﻩ ﻲ ﻤﺴﺤﺎﺕ ﻋﻠﻰ ﺍﻟﺼﺩﻴﺩ ﻋﻴﻨﺎﺕ ﺠﻤﻊ ﺍﻟﺩﺭﺍﺴﺔ ﺃﻭ ﺒﻐـﺯﺓ ﺍﻟـﺸﻔﺎﺀ ﻤﺴﺘﺸﻔﻰ ﻤﻥ ﻤﺭﻀﻰ ﻤﻥ ﺍﻟﻤﺤﺎﻗﻥ ﺒﻭﺍﺴﻁﺔ. ﺍﻟﺒﻜﺘﻴﺭﻴﺔ ﺍﻷﻭﺴﺎﻁ ﻋﻠﻰ ﺯﺭﻋﺕ ﺍﻟﻌﻴﻨﺎﺕ) ﺍﻟﻤﺎﻜﻭﻨﻜﻲ ﻭﺍﺠﺎﺭ ﺍﻟﺩﻡ ﺍﺠﺎﺭ.( ﺍﻤﺘﻠﻜـﺕ ﺍﻟﺘﻲ ﺍﻟﻌﺯﻻﺕ ﺍﻓﺘﺭﺍﺽ ﺘﻡ ﻋﻠﻰ ﺍﻻﻭﻜﺴﻴﺩﻴﺯ ﻓﺤﺹ ﻭﺴﺎﻟﺒﺔ ﺍﻟﺠﻠﻭﻜﻭﺯ ﺘﺨﻤﻴﺭ ﻋﺩﻡ ﺼﻔﺔ ﺃﻨﻬﺎ ﺍﺴﻴﻨﻴﺘﻭﺒﺎﻜﺘﺭ. ﻋ ﺘﻡ ﻤﺠﻤﻭﻋـﻪ ﻤﺎ ﺯل152 ﻟ ﻟﻠﻌـﺯﻻﺕ ﻋﺎﻟﻴـﺔ ﻤﻘﺎﻭﻤـﺔ ﺍﻟﺤـﺴﺎﺴﻴﺔ ﻓﺤـﺹ ﻨﺘـﺎﺌﺞ ﻭﺃﻅﻬـﺭﺕ ﺍﻻﺴﻴﻨﻴﺘﻭﺒﺎﻜﺘﺭ ﻤﻥ ﻋﺯﻟﺔ ﻤـﻥ ﻜـل Cephalosporins ) cephalexine, 98%, cefuroxime, 98.2% cefotaxime, 93.2%, ceftazidime, 87.5%, ceftriaxone, (93.3% cefaclor, 97.4%) ﺃﻗل ﻨﺴﺏ ﺍﻟﺩﺭﺍﺴﺔ ﺃﻅﻬﺭﺕ ﺒﻴﻨﻤﺎ ﺍﻟﻤ ﻤﻥ ﻀﺩ ﻘﺎﻭﻤﺔaminoglycosides (amikacin, 68.3% and gentamicin, 81.3%) . ﺍﻟﻤـﻀﺎﺩ ﻫﻭ ﺍﻟﻨﺘﺎﺌﺞ ﺍﻅﻬﺭﺕ ﻜﻤﺎ ﻓﻌﺎﻟﻴﺔ ﺍﻷﻜﺜﺭdoxycycline ﻤﻘﺎﻭﻤﺔ ﻨﺴﺒﺔ ﺒﺄﻗل) 22.1 % ( . ﺍﻟﺩﺭﺍﺴـﺔ ﻫـﺫﻩ ﻨﺘﺎﺌﺞ ﻭﺍﻟﺒﺤـﺙ ﺍﻟﻤﺴﺘﺸﻔﻴﺎﺕ ﻓﻲ ﺍﻻﺼﺎﺒﺔ ﻤﺨﺎﻁﺭ ﻟﺘﻘﻠﻴل ﻋﻤﻠﻴﺔ ﺒﺨﻁﻭﺍﺕ ﺍﻟﻘﻴﺎﻡ ﻭﻴﺠﺏ ﺇﻨﺫﺍﺭ ﺒﻤﺜﺎﺒﺔ ﺘﻌﺘﺒﺭ ﺃﻥ ﻴﺠﺏ ﺒﺩﻴﻠﺔ ﻤﻀﺎﺩﺍﺕ ﻋﻥ. ﻤﻔﺘﺎﺤﻴﺔ ﻜﻠﻤﺎﺕ: ﺍﻟﺤﻴﻭﻴﺔ ﺍﻟﻤﻀﺎﺩﺕ ﻤﻘﺎﻭﻤﺔ، ﺍﺴﻴﻨﻴﺘﻭﺒﺎﻜﺘﺭ. * Medical technology department, Faculty of Science, Islamic University of Gaza, Palestine. elmanama_144@yahoo.com .