S R Pattan et al Journal of Chemical and Pharmaceutical Research, 2009, 1(1):191-198 ______________________________________________________________________________ Available online at www.jocpr.com 191 Synthesis and biological evaluation of some 1, 3, 4-thiadiazoles Shashikant R Pattan* 1 , Prajact kekare 2 , Nachiket S Dighe 1 , Sunil A Nirmal 3 , Deepak S Musmade 1 , Smita K Parjane 1 and Aarti V Daithankar 1 1 Dept. of Medicinal Chemistry, Pravara Rural College Of Pharmacy, Pravaranagar, M.S.,India 2 Dept. of Medicinal Chemistry, K.L.E.S.College of Pharmacy, Belgaum, Karnataka, India 3 Dept. of Pharmacognosy, Pravara Rural College Of Pharmacy, Pravaranagar, M.S.India ______________________________________________________________________________ Abstract Thiadiazoles and their derivatives exhibit a wide variety of biological activities like antidiabetic, anti inflammatory, anti-convulsant etc.In the present study we have synthesized some substituted thiadiazoles. The structures of these synthesized compounds were confirmed by IR, NMR and CHN analysis. All the values and results of this spectral and elemental analysis are found to be in the normal range. These compounds were evaluated for various biological activities like Anti- diabetic, anti-inflammatory, anti-fungal activity. Key words: 1, 3, 4-thiadiazoles; antimicrobial; anti-inflammatory; antidiabetic activity. ______________________________________________________________________________ Introduction Diabetes mellitus is a heterogeneous group of diseases, characterized by a state of chronic hyperglycemia, resulting from a diversity of etiologies, environmental and genetic, acting jointly. The underlying causes of diabetes are the defective production or action of insulin, a hormone that controls carbohydrate, fat and protein metabolism. Characteristically diabetes is a long-term disease with variable clinical manifestations and progression, chronic hyperglycemia from whatever cause, leads to a number of complications including cardiovascular such as hypertension, renal, neurological such as anxiety, stress, ocular and other such inter-current infections. Diabetes Mellitus is a condition in which the pancreas no longer produces enough insulin or cells stop responding to insulin that is produced, so that glucose in the blood cannot be absorbed in to the cells of the body. Symptoms include frequent urination, lethargy, excessive thirst, and hunger. The treatment includes changes in diet, oral medications and in some cases daily injection of insulin. A large number of 1, 3, 4-thiadiazoles have been reported to be