Please cite this article in press as: Soto-Vega E, et al. Antiphospholipid antibodies in Mexican HIV-positive patients. Inmunología. 2012. http://dx.doi.org/10.1016/j.inmuno.2012.10.002 ARTICLE IN PRESS INMUNO-40; No. of Pages 5 i n m u n o l o g í a . 2 0 1 2; x x x(x x) :xxx–xxx Inmunología www. elsevier.es/inmunologia Original article Antiphospholipid antibodies in Mexican HIV-positive patients Elena Soto-Vega a,* , Alejandro Ruiz-Argüelles b , Claudia Mendoza-Pinto c , Jonathan R. Hernández-Molina d , Jose A. Varela-Cabrera a , María J. Mu ˜ noz-Pérez a , Nancy Labastida-Mercado a , Mario García-Carrasco c , Liliana Rivadeneyra-Espinoza a , Carlos Arroyo e a Facultad de Medicina, Ciencias de la Salud, Universidad Popular Autónoma del Estado de Puebla, Mexico b Laboratorios Clínicos de Puebla, Mexico c Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Mexico d Hospital Central Cruz Roja Mexicana, Mexico e Hospital Universitario de Puebla, Benemérita Universidad Autónoma de Puebla, Mexico a r t i c l e i n f o Article history: Received 13 July 2012 Accepted 17 October 2012 Available online xxx Keywords: HIV aCL antibodies Immunodeficiency a b s t r a c t Several studies have shown that HIV patients tend to develop autoimmune diseases, and have numerous antibodies, such as antiphospholipid antibodies. Antiphospholipid anti- bodies are the serological markers used in the diagnosis of the antiphospholipid syndrome. However, antiphospholipid antibodies also appear to exist in infectious diseases. Objective: To measure the titers of antiphospholipid antibodies in healthy and in HIV positive Mexican mestizo patients, and correlate them with the patient clinical manifestations to identify possible findings compatible with an autoimmune disease. Material and methods: A case control study was conducted on 50 healthy mixed race Mexi- can subjects and in 50 randomly selected HIV-positive patients from the Infectious Diseases Department of a Regional Hospital in Puebla, México. Antiphospholipid titers were per- formed on the patients and controls and analyzed to see if there was any correlation between clinical signs. Results: There was a statistical difference in the titers of anticardiolipin antibodies isotype IgG between the control group and the HIV group. When sexual preference was evalu- ated in the HIV group a statistical difference in the antibody titers was observed between homosexual and heterosexual HIV patients. Conclusion: There were no correlations found between the antibody titers and specific clin- ical manifestations in HIV positive patients. The exact clinical meaning of the presence of these antibodies in HIV positive patients is still unknown, so further studies are needed. © 2012 Sociedad Espa ˜ nola de Inmunología. Published by Elsevier España, S.L. All rights reserved. ∗ Corresponding author. E-mail address: elena.soto01@upaep.mx (E. Soto-Vega). 0213-9626/$ – see front matter © 2012 Sociedad Espa ˜ nola de Inmunología. Published by Elsevier España, S.L. All rights reserved. http://dx.doi.org/10.1016/j.inmuno.2012.10.002