Inverse association between programmed death ligand 1 (PDL1) and genes in the vascular endothelial growth factor (VEGF) pathway in primary clear cell renal cell (ccRCC). Richard W. Joseph 1 , Mansi Parasramka 2 , Jeanette E. Eckel-Passow 3 , Dan Serie 4 , Kevin Wu 5 , Jennifer Jiang 5 , Krishna Kalari 3 , R. Houston Thompson 6 , Thai Ho 7 , Erik Castle 8 , John Cheville 9 , Eugene Kwon 6 , E. Aubrey Thompson 2 , Alexander Parker 10 1. Department of Hematology and Oncology, Mayo Clinic Florida 2. Department of Cancer Biology, Mayo Clinic Florida 3. Department of Health Sciences Research, Mayo Clinic Rochester 4. Department of Health Sciences Research, Mayo Clinic Florida 5. Department of Pathology, Mayo Clinic Florida 6. Department of Urology, Mayo Clinic Rochester 7. Department of Hematology and Oncology, Mayo Clinic Arizona 8. Department of Urology, Mayo Clinic Arizona 9. Department of Pathology, Mayo Clinic Rochester 10. Department of Urology and Epidemiology, Mayo Clinic Florida Running title: Inverse relationship between angiogenesis and immune evasion in ccRCC Keywords: PDL1, VEGF, ccRCC, immunotherapy, immune evasion, angiogenesis Conflicts of Interest: The authors have nothing to declare. *Corresponding author: Richard W. Joseph, M. D. Assistant Professor Mayo Clinic Florida 4500 San Pablo Rd. Jacksonville, FL 32224 TEL: 904–953–7290 e-mail: Joseph.Richard@Mayo.edu on August 15, 2016. © 2013 American Association for Cancer Research. cancerimmunolres.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on August 29, 2013; DOI: 10.1158/2326-6066.CIR-13-0042