CONCLUSIONS: The AdVance XP shows good and stable effectiveness and low complication rates in a follow-up of up to 2 year. However overtensioning of the sling especially during removal of the Tyvek liners resulting in persistent urinary retention is possible. Source of Funding: American Medical Systems MP88-10 IMPACT OF RADIOTHERAPY ON URINARY CONTINENCE AND QOL AFTER RADICAL PROSTATECTOMY Joanne Nyarangi-Dix*, Johannes Steimer, Hildegard Jakobi, Boris Hadaschik, Markus Hohenfellner, Heidelberg, Germany INTRODUCTION AND OBJECTIVES: To investigate the influ- ence of time of initiation of and indication for radiotherapy (RT) on uri- nary continence and QOL-outcomes after radical prostatectomy. METHODS: The Heidelberg prospective tumor-data-base was searched for men receiving RT after radical prostatectomy (RP). These were assigned in adjuvant (ART), early salvage (ESRT) and salvage radiotherapy (SRT) groups depending on time, indication and pre-RT- PSA (¡ € U/>0.5ng/ml). We evaluated patient-reported urinary continence and QOL-outcomes. RESULTS: Complete data was available for 251 men. Mean follow-up was 5.1years (range: 0.4-22.4yrs.). 84, 96 and 71 men received ART, ESRT, and SRT respectively. Mean time to RT was 0.3(¡  A0.4), 1.8(¡  A2.5) and 3.3(¡  A3.6) years. respectively. Mean age at RP and RT was 63.9(¡  A6.1) and 65.7(¡  A6.2) years respectively; differ- ences in age at RP (p¼0.54) and RT (p¼0.47) between groups were not significant. Mean-RT-dose was similar (p¼0.70). Overall continence rate was 61.4%. No significant difference was found in continence distribution between groups prior (p¼0.56) to and after RT (p¼0.38). We also found no significant differences in frequency (p¼0.58) or amount of urine loss (p¼0.88), impact on QOL (p¼0.13) and ICIQ-SF scores (p¼0.69) between groups. Even though there was no significant dif- ference in post-RT-continence in the direct comparison between study groups (p¼0.89), a significant longitudinal worsening of continence was noted (p< 0.001). CONCLUSIONS: This is the first analysis evaluating the impact of time of initiation and indication for RT on urinary continence. We demonstrate that RT adversely affects postoperative continence. This negative effect is irrespective of time of initiation of RT or indication for RT. Source of Funding: None MP88-11 EXTERNAL BEAM RADIATION THERAPY AFTER MALE TRANSOBTURATOR SLING PLACEMENT INCREASES FAILURE RATES Divya Ajay*, John Selph, Michael Belsante, Ngoc-Bich Le, Durham, NC; Aaron Lentz, Raleigh, NC; George Webster, Andrew Peterson, Durham, NC INTRODUCTION AND OBJECTIVES: Post-prostatectomy stress urinary incontinence (PPSUI) is a wellrecognized side ef- fect of treatment for prostate cancer that negatively impacts quality of life. There is ample evidence to suggest that patients who un- dergo external beam radiation therapy (EBRT) prior to trans- obturator sling (TOS) placement have high rates of TOS failure. However, whether EBRT delivered for biochemical recurrence after TOS placement affects continence outcomes is not known. Our objective was to evaluate TOS outcomes in patients with post- sling EBRT. METHODS: We conducted an IRB approved review of all pa- tients undergoing a male TOS placement from 2006 to 2012 at our institution. Patients who underwent placement of TOS were identified using our patient data portal (DEDUCE). Demographic and follow-up data were extracted by chart review. Success was defined post-oper- atively by the use of 0 or 1 security pad, a negative stress test on exam, or pad weight of less than 8 g per 24 hours. Student’s T-test was performed. RESULTS: During this time period 290 TOS were performed. Of these, we identified 11 patients who received EBRT after TOS place- ment. All of these underwent a radical prostatectomy for prostate cancer and presented with PPSUI. Average age at TOS surgery was 66.3 years ( 7.4). They underwent EBRT at a median of 18 months (IQR 11-38) from TOS placement. 8/11 (73%) were dry prior to EBRT. Of the patients who were dry, 87.5% (7/8) reported TOS failure after EBRT treatment at a median of 0 months (IQR 0-11) from the end of radiation therapy. This is in comparison to a 42.6% overall failure rate in the entire cohort (p<0.01). CONCLUSIONS: EBRT delivered after male TOS placement may cause TOS failure. This information will be helpful in clinical de- cision making for PPSUI patients with advanced stage prostate cancer or with positive surgical margins at radical prostatectomy who may need adjuvant EBRT. Source of Funding: None MP88-12 EFFECTS OF RADIATION THERAPY ON DEVICE SURVIVAL AMONG INDIVIDUALS WITH ARTIFICIAL URINARY SPHINCTERS Marcelino Rivera*, Matthew Ziegelmann, Brian Linder, Boyd Viers, Laureano Rangel, Daniel Elliott, Rochester, MN INTRODUCTION AND OBJECTIVES: Literature surrounding artificial urinary sphincter (AUS) device survival among individuals with a history of radiation therapy is conflicting with limited data to date. Therefore, we aim was to assess AUS device survival outcomes among individuals with prior radiation therapy exposure undergoing AUS placement. METHODS: An institutional review board approved database of all AUS patients from 1999-2014 was utilized to assess device survival in patients who underwent radiotherapy compared to in- dividuals without radiotherapy exposure. Kaplan-Meier analysis was performed to determine survival including overall device and erosion/ infection-free survival. Hazard regression analysis was utilized to determine the association between radiation therapy and device outcomes. RESULTS: From 1999-2014 a total of 1,153 patients under- went AUS surgery at our institution. Of these, a total of 650 under- went primary AUS placement with 285 (44%) having received radiation therapy. When compared with patients who did not receive radiation therapy those who did were older (median age 72.8 vs 70.2, p<0.0001), had a greater BMI (28.9 vs 28.1, p<0.0019), and higher rates of diabetes and hypertension (HTN) (p<0.02 and <0.009 respectively). On univariate analysis, only age was signifi- cantly associated with AUS overall device survival (HR 0.976, p<0.002). Likewise, survival analysis demonstrated no significant difference in 1 and 5-year overall device (88% vs 84% and 62% vs 57% respectively, p¼0.5) and erosion/infection-free survival (94% vs 92% and 89% vs 89% respectively, p¼0.7) rates among individuals who received radiation therapy relative to those without radiation therapy exposure. CONCLUSIONS: While individuals who underwent radiation therapy were significantly older, had a higher BMI and higher rates of diabetes and HTN, device survival, as well as infection/erosion rates were not significantly different between the two groups. Clinically, these findings will assist the urologist with preoperative counseling of men undergoing primary AUS placement with a history of radiation therapy. e1096 THE JOURNAL OF UROLOGY â Vol. 193, No. 4S, Supplement, Tuesday, May 19, 2015