Trends in Cell Biology Volume 15, Issue 11, Pages 565-632 (November 2005) 1. Contents page + Editorial Board • EDITORIAL BOARD Page i Update 2. Modulating molecular chaperone Hsp90 functions through reversible acetylation • SHORT SURVEY Pages 565-567 Sayura Aoyagi and Trevor K. Archer 3. Intermediate filament proteins participate in signal transduction • SHORT SURVEY Pages 568-570 Brian T. Helfand, Ying-Hao Chou, Dale K. Shumaker and Robert D. Goldman 4. Possible regulation of microtubules through destabilization of tubulin • SHORT SURVEY Pages 571-573 Christian E. Keller and Brett P. Lauring Opinion 5. Cell toxicity and conformational disease • ARTICLE Pages 574-580 Robin W. Carrell 6. The mechanism of cortical ingression during early cytokinesis: thinking beyond the contractile ring hypothesis • ARTICLE Pages 581-588 Yu-li Wang