Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research __________________________________________________ ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(4):5-9 5 Synthesis of novel Schiff bases and its transition metal complexes M. Mustapha, B. R. Thorat, Sudhir Sawant, R. G. Atram and Ramesh Yamgar* P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai, INDIA ______________________________________________________________________________ ABSTRACT Novel transition metal [Cu(II), Ni(II), Zn(II), La(II)] complexes of bidentate Schiff base ligand obtained from 2-hydroxy-3-formylquinoline and substituted p-iodoaniline have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff base act as bidentate ligand for the complexation reaction with Cu(II), Ni(II), Zn(II) and La(II) ions. The new compounds, possessing the general formula [M(L) 2 ] where [M= Cu(II), Ni(II), Zn(II) and La(II)] show square planar geometry. Key words: Schiff bases, quinoline, transition metal complexes of Cu(II), Zn(II), Ni(II) and La(III). ______________________________________________________________________________ INTRODUCTION Schiff bases derived from condensation of aromatic aldehydes and aromatic amines form an important group of compounds in synthetic chemistry due to their useful physical and chemical properties and large number of reactions they undergo. Schiff bases are also used widely in pharmaceutical industry and have interesting pharmacological activities [1-5]. Among the organic reagents actually used, Schiff bases possess excellent characteristics, structural similarities with natural biological substances, relatively simple preparation procedures and the synthetic flexibility that enables design of suitable structural properties . Many biologically important Schiff bases have been reported in the literature possessing, antibacterial,antifungal,antimicrobial, anticonvulsant, antiHIV , anti-inflammatory , antitumor and catalytic activities.[6-11]