1 | Page BRACHYURY confers cancer stem cell characteristics on colorectal cancer cells Debalina Sarkar 1 , Brian Shields 1 , Melanie L. Davies 1 , Jürgen Müller 1,2 and Jane A.Wakeman 1 * 1. North West Cancer Research Fund Institute, School of Biological Sciences, Bangor University, Brambell Building, Deiniol Road, Bangor, Gwynedd LL57 2UW 2. Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV47AL * Corresponding author: j.a.wakeman@bangor.ac.uk , Tel: 44 (0)1248 382341 Fax: 44 (0) 1248 370731 Keywords: Brachyury, colorectal cancer, cancer stem cells, Nanog Article Category: Cancer Cell Biology Page 1 of 39 John Wiley & Sons, Inc. International Journal of Cancer