right atrium is accepted by the investigator, changes
cannot be made afterward in the present version. At
times, this may not be advantageous, because a more
accurate representation of the area of interest (atrial
focus) could become necessary during the study.
A potential advantage of the non-contact mapping
system may be the capability to localize and ablate
tachycardias that are unstable or short lasting. Al-
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ablating these tachycardias, the number of patients
included in this study is low. The potential advantage
of the non-contact mapping system over conventional
catheter techniques needs to be shown in a larger
randomized study.
Use of the new high-resolution non-contact
mapping system in patients with focal right atrial
tachycardias is safe and effective in identifying and
ablating the tachycardia origin. With this system,
diagnosis and ablation procedures in patients with
unstable tachycardias is facilitated.
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Exercise Capacity After Repair of Tetralogy of
Fallot in Infancy
Anji T. Yetman, MD, Kyong-Jin Lee, MD, Robert Hamilton, MD, William R. Morrow, MD,
and Brian W. McCrindle, MD, MPH
T
he long-term outcome of children after complete
repair of tetralogy of Fallot (ToF) has been well
described.
1,2
Impairment in exercise tolerance has
been frequently reported
3–6
and speculated to be due
to a number of causes including residual right ventric-
ular (RV) outflow tract obstruction,
7
branch pulmo-
nary artery stenoses,
6
pulmonary insufficiency,
3,5,7–9
chronotropic incompetence,
4
and pulmonary patholo-
gy.
10 –12
Published reports have focused on children
with an older age at repair.
1–5,7,10 –14
Repair in infancy
frequently necessitates placement of a transannular
patch, and raises concerns as to the long-term effect of
chronic pulmonary insufficiency in those repaired at
an early age. Although there is a growing body of
published data on those repaired in early childhood,
6,8
the long-term impact on aerobic capacity in those
repaired during infancy remains unknown. We sought
to assess long-term outcome of children with ToF
repaired in infancy (age 18 months), with an em-
phasis on cardiopulmonary exercise performance, and
to identify any potential factors associated with im-
paired aerobic capacity. In addition, we sought to
compare exercise performance in children repaired in
infancy with that in similar children who were re-
paired at an older age.
•••
Cardiopulmonary stress testing and echocardiogra-
phy were performed in 74 patients who underwent
repair of ToF between 1982 and 1992 at 1 of 2 tertiary
cardiac centers. Within this study population, a sub-
group of 22 patients repaired at an age 18 months
was identified and served as the focus of this study,
with the remaining patients who were repaired at a
later age serving as a comparison group. The period of
1982 to 1992 was chosen for review, because there
From the Department of Pediatrics, Divisions of Cardiology, Arkansas
Children’s Hospital, Little Rock, Arkansas; and The Hospital for Sick
Children, Toronto, Ontario, Canada. Dr. Yetman’s address is: Depart-
ment of Cardiology, Arkansas Children’s Hospital, 800 Marshall
Street, Little Rock, Arkansas 72202. E-mail: yetmananjit@
exchange.uams.edu. Manuscript received September 19, 2000; re-
vised manuscript received and accepted November 1, 2000.
1021 ©2001 by Excerpta Medica, Inc. All rights reserved. 0002-9149/01/$–see front matter
The American Journal of Cardiology Vol. 87 April 15, 2001 PII S0002-9149(01)01443-6