7 Journal of Applied Pharmaceutical Sciences – JAPHAC, 2016; 3(1): 7-17. Delziovo et al., 2016 The Outcome of Multibacillary Patients infected with Mycobacterium leprae treated with Multidrug Therapy associated with the Biotherapic Tuberculinum 30 CH Andressa Silveira Delziovo 1 , Walace Olímpio de Oliveira 2 , Gulnara Patricia Borja-Cabrera 3 * 1 - Master of Biological Sciences, University Vale do Rio Doce, Governador Valadares, Brazil. 2 - PharmBSc, University Vale do Rio Doce, Governador Valadares, Brazil. 3 - Ph.D., professor of Masters in Integrated Management of the Territory, University Vale do Rio Doce, Brasil. *Corresponding Author: gulnara.borja@univale.br _____________________________________________________________________________ Abstract: Leprosy is a public health problem in Brazil. The multidrug therapy is the main strategy to break the chain of transmission of Mycobacterium leprae. The WHO created a Program of Traditional Medicine, in order to formulate policies on traditional and complementary medicine and has expressed its commitment to encourage in the endemic countries, the use of homeopathy in national health care systems and to develop scientific studies to better understand this therapy. In Brazil, the Ministry of Health approved the National Policy on Integrative and Complementary Practices as homeopathy, in the Unified Health System. In order to evaluate the effects of homeopathy in the treatment of leprosy the clinical response of multibacillary individuals infected with Mycobacterium leprae, undergoing treatment with biotherapic Tuberculinum 30 CH, obtained from Mycobacterium tuberculosis culture, considered a biotherapic Codex, was evaluated as an adjunct in the conventional therapy and compared with the response of multibacillary individuals submitted to the conventional regimen only. The clinical outcome was assessed by mean and the confidence interval 95% of scores. The results showed the lowest clinical score and type 1 and 2 leprosy reactions, in the Tuberculinum 30 CH group, suggesting that the improvement is a result of homeopathy. Further studies should be performed to evaluate the immunomodulatory effect in the pathogenesis of the disease. Key words: leprosy, homeopathy, biotherapic Tuberculinum. Introduction Leprosy is a chronic infectious granulomatous disease of compulsory and mandatory investigation and notification, caused by Mycobacterium leprae. Throughout the history, many ideas and prejudices concerning leprosy were related to manifestations of discrimination, due to mutilation caused by the disease in the pre- chemotherapy era. From the beginning of multidrug therapy (MDT), a complete change of this panorama was allowed, making it curable with immediate impact on transmission? as early as the first medication doses, when the bacilli become unviable 1 . Brazil leads the second largest country in notifications, preceded only by India. According to the World Health Organization (WHO), 34894 new cases were reported in the country in 2010 2 . Data from the Brazilian Notifiable Diseases Information System (SINAN) showed that in 33955 new notified cases in 2011, 7.1% of patients were under 15 years old and 7.2% had grade 2 of disability 3 . The diagnosis of leprosy case is essentially clinical and epidemiological, being carried out by analyzing the history and living conditions of the patient, the skin examination to identify lesions or skin areas Submitted: 22-02-16 Corrected version:15-03-16 Accepted in:18-03-16