CONTENTS Chapter 1 General introduction 7 Chapter 2 Removal of the Charité lumbar artificial disc prosthesis. Surgical 19 technique Journal of Spinal Disorders and Techniques. 2009;22:334‐9 Chapter 3 Complications and reoperations of the SB Charité lumbar disc 31 prosthesis: Experience in 75 patients European Spine Journal. 2008;17:36‐43 Chapter 4 Mid‐term results of two revision strategies for failed total 47 disc replacements Submitted Chapter 5 Undersizing of a total disc replacement and subsidence 59 In preparation Chapter 6 Periprosthetic tissue reactions observed at revision of total 73 intervertebral disc arthroplasty Biomaterials. 2009;30:2079‐84 Chapter 7 Are periprosthetic tissue reactions observed after revision of 89 total disc replacement comparable to the reactions observed after total hip or knee revision surgery? Spine. 2011 Epub ahead of print, Feb 17 Chapter 8 Submicron–sized UHMWPE wear particle analysis from revised 107 SB Charité III total disc replacements Biomateralia. 2011;7: 3404‐11 Chapter 9 General discussion 125 Summary 137 Samenvatting 143 Dankwoord 149 List of publications 155 Curriculum Vitae 159 Colour figures 163