Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (3):170-177 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 170 Scholar Research Library Formulation development and evaluation of glyburide beads for controlled release D. Lohithasu *1 , I. N. S. Harsha *1 , K. Krishna Swaroop 2 , G. Madhu 3 , S. Bhagyalakshmi 3 and K. Lavanya 3 1 GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, A.P., India 2 Srinivasarao College of Pharmacy, Visakhapatnam, A.P., India 3 Viswanadha Institute of Pharmaceutical Sciences, Visakhapatnam, A.P., India _____________________________________________________________________________________________ ABSTRACT Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. this present study an attempt was made to formulate controlled release beads of Glyburide by using Sodium alginate, HPMC K100M, Carbopol 940 and Calcium Chloride(fused).Beads were successfully prepared by Ionotropic Gelation Method .The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, Mean particle size, flow properties and in vitro release. The yields were varies from 88-93.8% and encapsulation efficacy is up to 91.2% which encourage the investigation. The in-vitro dissolution profile of optimized formulation batch i.e., F4 is resulted up 12 hours. The various parameters of model equation of beads containing Glyburide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics. Keywords: Glyburide, Microspheres, Sodium alginate, HPMC K 100 M and Carbopol 940. _____________________________________________________________________________________________ INTRODUCTON Oral drug delivery is the most used and preferred route of administration with the obvious advantage of ease of administration and patient acceptance. To develop a drug delivery system for oral administration, it is necessary to optimize not only the release rate of an active ingredient from the system but also the residence time of the system in the gastrointestinal tract[1]. our population afflicted with diabetes specially the Type-2, which are not dependent on insulin production.The efficiency of any drug therapy can be described by achieving desired concentration of the drug in blood or tissue, which is therapeutically effective and non toxic for a prolonged period. This goal can be achieved on the basis of proper design of the dosage regimen. Microspheres have potential to deliver drug in a controlled fashion. [2] Glyburide is a second-generation sulfonyl urea that is an orally bioavailable hypoglycemic agent used in the management of type 2 diabetes. Different research has reported that glyburide has a low bioavailability, which is attributed to its poor dissolution properties. It has short half life of 4-6 hours. Glyburide in oral conventional dosage form has the dosage regime of three times a day due to having short elimination half life of 5 hour. Controlled release concept and technology has received increasing attention in the face of growing awareness to toxicity and ineffectiveness of drugs. When drugs are administered as conventional dosage forms such as tablets, capsules etc. usually produce wide ranging fluctuations in drug concentration in the blood stream and tissues and consequently undesirable toxicity and efficiency[3].