www.wjpr.net Vol 3, Issue 4, 2014. 479 Lohithasu et al. World Journal of Pharmaceutical Research A LATEST REVIEW ON LIQUISOLID TECHNIQUE AS A NOVEL APPROACH D.Lohithasu* 1 , J. V.Ramana. 2 , P.Girish 2 , I.N.S. Harsha 2 ,G.Madhu 4 ,K.Lavanya 4 and D..Swathi Sri 3 1 K. G. R. L. College of Pharmacy, Bhimavaram, West Godavari, A.P, India. 2 GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, A.P, India. 3 VIGNAN Institute of Pharmaceutical Technology, Visakhapatnam, A.P, India. 4 VISWANADHA Institute of Pharmaceutical Sciences, Visakhapatnam, A.P, India. ABSTRACT The bioavailability and solubility were major challenge for the pharmaceutical industry with developments of new pharmaceuticals. The liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. Generally, Water- miscible organic solvent systems with high boiling point like propylene glycol, polyethylene glycols, or glycerine are used as liquid vehicles for improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility in liquisolid technique. When the carrier is saturated with liquid, a liquid layer is formed on the particle surface which is instantly adsorbed by the fine coating particles forming a dry, free flowing and compressible powder. Generally, Micro Crystalline Cellulose is used as carrier and silicon dioxide as coating material in liquisolid technique. Liquisolid compacts of poorly soluble drugs containing a drug solution or drug suspension in a solubilising vehicle show enhanced drug release with increased surface area of drug release, increased aqueous solubility and improved wettability of the drug particles. There are various methods but liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. In liquisolid technique, suspension and solution of solid drugs in non-volatile solvent systems and liquid drug convert into solid dosage form by using carriers and coating materials. Liquisolid system is characterized by flow behaviour pattern, wettability, powder bed hydrophilicity, saturation solubility, drug World Journal of Pharmaceutical Research SJIF Impact Factor 5.045 Volume 3, Issue 4, 479-493. Review Article ISSN 2277 – 7105 Article Received on 15 April 2014, Revised on 08 May 2014, Accepted on 01 June 2014 *Correspondence for Author D. Lohithasu K. G. R. L. College of Pharmacy, Bhimavaram, West Godavari, A.P, India.