Open Access Journal Indian Journal of Medical Research and Pharmaceutical Sciences September 2016; 3(9) ISSN: ISSN: 2349-5340 DOI: 10.5281/zenodo.61776 Impact Factor: 3.052 © Indian Journal of Medical Research and Pharmaceutical Sciences http://www.ijmprs.com/ [28] AREA UNDER CURVE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CEFPODOXIME PROXETIL IN SINGLE COMPONENT TABLETS Santosh Karajgi*, Raghavendra Kulkarni, Somashekhar Metri and Ashwini Wadekar *Dept. of Quality Assurance, BLDEA’s SSM College of Pharmacy, Vijaypur 586103 Abstract Keywords: Cefpodoxime Proxetil; Estimation; Area under curve; UV spectrophotometri; single component; tablets. An UVspectrophotometric area under curve method is developed for the estimation of Cefpodoxime Proxetil in its single component tablets. The new method is area under curve method for the analysis of Cefpodoxime Proxetil using methanol as solvent for the drug. Cefpodoxime Proxetil has absorbance maxima at 235nm at area under curve wavelength range of 230nm-240nm. Cefpodoxime Proxetil obeys Beer’s law in concentration range 10-50μg/ml. The recovery studies ascertained accuracy of the proposed method; results validated according to ICH guideline. Results were found satisfactory and reproducible. The method was successfully for evaluation of Cefpodoxime Proxetil in tablet dosage form without interference of common excipients. Introduction Cefpodoxime Cefpodoxime Proxetil is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative organisms. The antibacterial action of Cefpodoxime Proxetil is through inhibition of bacterial cell wall synthesis probably by acylation of membrane bound trans peptidase enzymes; this prevents cross linkage of peptidoglycan chains, which is necessary for bacterial cell wall strength and rigidity. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. [1] So far, ten methods are reported for the determination of Cefpodoxime Proxetil in dosage forms. Of these methods, eight methods are by HPLC determination [2-6] four UV-Spectrophotometric methods by zero order method [7 and 8] and one method by Hydrotropic Solubilization method [9].