~ 156 ~ ISSN Print: 2394-7500 ISSN Online: 2394-5869 Impact Factor: 5.2 IJAR 2016; 2(7): 156-158 www.allresearchjournal.com Received: 22-05-2016 Accepted: 23-06-2016 Gaikwad SB Department of Chemistry, Late Pundalikrao Gawali Arts and Science Mahavidyalaya, Shirpur (Jain), Washim, Maharashtra, India. BK Shelke Department of Chemistry, Shree Shivaji Polytechnic Institute, Parbhani, Maharashtra, India. SS Rokade Department of Botany, Late Pundalikrao Gawali Arts and Science Mahavidyalaya, Shirpur (Jain), Washim, Maharashtra, India. SR Bembalkar Department of Chemistry, Deogiri College, Aurangabad, Maharashtra, India. Correspondence Gaikwad SB Department of Chemistry, Late Pundalikrao Gawali Arts and Science Mahavidyalaya, Shirpur (Jain), Washim, Maharashtra, India. The LiFe5O8 an efficient catalyst for one pot synthesis of β-amino ketones under microwave irradiation Gaikwad SB, BK Shelke, SS Rokade and SR Bembalkar Abstract The LiFe5O8 catalyzed one pot three component Mannich type reaction of Acetophenone, aromatic aldehydes and aniline done by using ethylene glycol as a solvent in microwave irradiation. This reaction gives good yield of β-amino ketones. Keywords: Lithium ferrite, Mannich reaction, aniline, aromatic aldehydes and acetophenone. Introduction The Mannich type reactions are very important carbon-carbon bond forming reactions in organic synthesis and one of the most widely utilized chemical transformations for the formation of β-amino ketones and other amino carbonyl compounds, which are important synthetic intermediates for various pharmaceutical and natural products [1, 2] . Therefore, the development of new synthetic methods leading to β-amino carbonyl compounds or their derivatives has attracted much attention. However, the classic Mannich reaction has limited applications. To overcome the drawbacks of the classic method, numerous modern versions of the Mannich reaction using performed electrophiles, such as imines and stable nucleophiles, such as enolates, enol ethers, and enamines [3] have been developed. Conventional catalysts for the classical Mannich reaction of aldehydes, ketones and amines involve mainly Lewis acids [4-5] , Bronsted acids [6-7] and Lewis base catalysts [8] . However, sulfonated poly (4-vinylpyridine) heteropolyacid salts [9] , GuHCl [10] , CeCl3.7H2O [11] , sulfated MCM-41 [12] ionic liquids [13] have been found to catalyze this reaction. These catalysts suffer mainly from the drawbacks of long reaction time, toxicity and their use as in stoichiometric amounts. While searching for economical, cheap and better catalysts, we thought it worthwhile to perform a controlled reaction condition for the Mannich reaction using solid acid catalyst. Lithium ferrite and mixed lithium ferrites have very high potential for microwave applications, especially as replacements for garnets, due to their low cost. The squareness of the hysteresis loop and superior temperature performance are other prominent advantages that have made them very promising candidates for application in microwave devices. Microwave promoted reactions are well known as environmentally benign methods that also usually provide enhanced reaction rates, cleaner products and manipulative simplicity. However, these procedures are practically limited as the solvents in microwave oven at elevated temperature create high pressure, which may cause explosion. To circumvent these problems there is need for the development of newer methods which proceed under mild condition. 2. Material and Methods 2.1 The synthesis of β-amino ketones A mixture of Benzaldehyde (1.0 mmole), Acetophenone (1.0 mmole) and Aniline (1.0 mmole) and (10 mole %) lithium ferrite and ethylene glycol as a solvent where taken in beaker. The reaction mixture was irradiated in microwave oven at 80 ο C temperatures for the précised time shown in (Table 1). The progress of the reaction was monitored by TLC. After completion, the reaction mass was cool and poured over crushed ice and solid was obtained, purified by recrystallization. The products were confirmed by melting point comparisons with authentic samples. International Journal of Applied Research 2016; 2(7): 156-158