Seroprevalence of Bartonella henselae in Dogs and Cats in Sassari M.L. Pinna Parpaglia 1,* , G. Masu 2 , G. Masala 2 , R. Porcu 2 , R. Zobba 1 , G. Pintori 1 and R. Cocco 1 1 Institute of Special Pathology and Veterinary Clinical Medicine - Faculty of Veterinary Medicine, Sassari, Italy; 2 Experimental Zooprophylactic Institute of Sardinia, Sassari, Italy * Correspondence: E-mail: pinnapar@uniss.it Pinna Parpaglia, M.L., Masu, G., Masala, G., Porcu, R., Zobba, R., Pintori, G. and Cocco, R., 2007. Veterinary Research Communications, 31(Suppl. 1), 317–320 Keywords: Bartonella henselae, cat, dog, seroprevalence Abbreviations: CSD, cat-scratch disease; IgG, immunoglobulin G; IgM, immunoglobulin M INTRODUCTION Bartonella spp. belong to the a 2 subgroup of the class Proteobacteria, family Bartonel- laceae and genus Bartonella which comprises many species, eleven of which have been shown to be pathogens for humans (Chomel et al., 2006). Bartonellosis is considered an emerging zoonosis for the increase of clinical cases in humans and for the mount of spe- cies involved (Fenollar et al., 2005). Since 1992 Bartonella henselae has been consid- ered the main causative agent of BCat Scratch Disease^ (CSD). The most frequent route of transmission to humans is via cat bites and scratches which, in natural conditions, very rarely manifest clinical signs, even if they remain bacteremic for a long period of time (Fabbi et al., 2004a). Persistent bacteremia (>2 years) in asymptomatic cats repre- sents the most important factor that facilitates the spread of the microorganism (Marsilio and Di Martino, 2005). Six species of Bartonella have been identified as pathogens in dogs and among them there is Bartonella henselae (Mesax et al., 2002; Chomel et al., 2006), which was reported for the first time in 2000 as causative agent of disease in dog (Kitchell et al., 2000). Some vectors, such as ticks and fleas, have an important role for the transmission of infection. In fact, during the blood meal they can transmit the infec- tion to other animals and so they are able to maintain or reproduce the bacterium in the organism (Boulouis et al., 2005; Chomel et al., 2006). MATERIALS AND METHODS In a search plan about epidemiological and clinical aspects of zoonotic diseases in dogs and cats, the seroprevalence of Bartonella henselae was studied in a population of 205 dogs (116 males and 89 females) between two months and fifteen years of age and 79 317 Veterinary Research Communications, 31(Suppl. 1) (2007) 317–320 DOI: 10.1007/s11259-007-0056-x # Springer 2007