ISSN: 2320-5407 Int. J. Adv. Res. 4(8), 1580-1588 1580 Journal Homepage: -www.journalijar.com Article DOI: Article DOI:10.21474/IJAR01/1365 DOI URL: http://dx.doi.org/10.21474/IJAR01/1365 RESEARCH ARTICLE EVALUATION OF PROTECTIVE AND THERAPEUTIC POTENTIAL OF CURCUMIN ON CADMIUM CHLORIDE INDUCED RESPIRATORY TOXICITY IN SWISS ALBINO MICE ( MUS MUSCULUS) ON THE BASIS OF HISTOPATHOLOGICAL, HISTOENZYMOLOGICAL AND BIOCHEMICAL ASSESSMENT. Preeti Singh and Sweety Gupta. Cytogenetic & Endocrinology Research laboratory, Department of Zoology, College of Science, Mohan LalSukhadia University, Udaipur Rajasthan, 313001, India. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 18 June 2016 Final Accepted: 19 July 2016 Published: August 2016 Key words:- Curcumin, cadmium chloride, toxicity, lactate dehydrogenase, lung. Curcumin derived from turmeric has been attributed with immense potential to combat innumerable ailments, especially inflammation related disorders. In contrast to the beneficial effects of curcumin cadmium an omnipresent transitional element, is a known environmental toxicant of twentieth century. Hence the aim of the present study was to evaluate the protective and therapeutic potential of curcumin on cadmium chloride induced respiratory toxicity in Swiss Albino Mice (Musmusculus) on the basis of histopathological, histoenzymological and biochemical assessment. The study constituted of three experimental groups, each comprising of six mice viz. Control group- administered only vehicle; (a) experimental group administered curcumin (10mg/animal/day); (b) experimental group administered cadmium chloride (50mg/kg/animal/day) and (c) experimental group administered curcumin (10mg/animal/day) for 15 days and on the 16th day administered cadmium chloride (50mg/kg/animal/day). As compared to control group, lungs of only cadmium treated mice showed altered histopathological profile, as manifested by thickening of interalveolar septa, aggregation of lymphocyte infiltration etc. These cadmium treated mice assessed for lactate dehydrogenase by biochemical and histoenzymological means showed significant elevated distribution pattern. In experimental group pretreated with curcumin did not reveal such acute histopathological deterioration and in the histochemical profile the assessed biochemical levels were similar to that of control. Copy Right, IJAR, 2016,. All rights reserved. …………………………………………………………………………………………………….... Introduction:- Curcumin is a polyphenol herbal remedy obtained from the rhizome of dietary spice turmeric, commonly used as a yellow coloring and flavoring agent in food. It is biologically active, non – toxic chemical that has been used as a protective and therapeutic agent since ancient times in treatment of various aliments viz. wound healing, bruises, insect bites, jaundice, diabetic wounds, asthma, fever, cold, cough, blood purifier, in skin disease and hepatic disorders etc. (Soni and Kuttan 1992; Venkatesanet al.1997; Asai and Miyazawa 2001; Shahedet al. 2001 and Corresponding Author:-Preeti Singh. Address:-Cytogenetic & Endocrinology Research laboratory, Department of Zoology, College of Science, Mohan LalSukhadia University, Udaipur Rajasthan, 313001, India.