NADYA-NOVA BOOK-BASU-06-3016- 4: 30 PM.docx Chapter-10 BIOSYNTHESIS OF LEX FAMILY GLYCOSPHINGOLIPIDS AND ITS GENE REGULATION: XIV. IN APOPTOTIC BREAST CARCINOMA CELLS Subhash Basu 1,* , Ma Rui 2, ‡ , Joseph R. Moskal 3,† and Manju Basu 1,§ 1 Department of Chemistry and Biochemistry and Cancer Drug Delivery Research Foundation, University of Notre Dame, Notre Dame, IN, US 2 Diagnostic Div. Siemens Corporation, Shanghai, China 3 The Falk Center for Molecular Therapeutics, Northwestern University, Evanston, IL, US ABSTRACT In human bodies most of the normal cells in their life cycle die through apoptosis (programmed cell death). However, metastatic cancer cells die mostly by Necrosis where, through the cell surface pores, degraded products and newly expressed unfriendly compounds come out and cause death of normal vicinal cells. Apoptotic, or programed cell death of normal cells, is less toxic and is absent in cancer cells to achieve * E-mail: sbasu@nd.edu, Subhash.C.Basu.2@nd.edu. ‡ E-mail: ma.rui@siemens.com. † E-mail: j-moskal@northwestern.edu. § E-mail: mbasu@nd.edu, Manju.Basu.1@nd.edu.