E-Mail karger@karger.com Original Paper Ann Nutr Metab 2013;63:239–247 DOI: 10.1159/000353211 Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease: Do They Influence Patient-Related Outcomes? Erica P.A. Rutten   a Peter M.A. Calverley   b Richard Casaburi   c Alvar Agusti   d, e Per Bakke   f Bartolome Celli   g, h Harvey O. Coxson   i Courtney Crim   j David A. Lomas   k William MacNee   l Bruce E. Miller   m Stephan I. Rennard   n Paul D. Scanlon   o Edwin K. Silverman   g, h Ruth Tal-Singer   m Jørgen Vestbo   p–r Michael L. Watkins   j Emiel F.M. Wouters   s  on behalf of the ECLIPSE Investigators (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints)  a  Center of Expertise for Chronic Organ Failure (Ciro+), Horn, The Netherlands; b  The University of Liverpool, Liverpool, UK; c  Rehabilitation Clinical Trail Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, Calif., USA; d  The Thorax Institute, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, and e  CIBER Enfermedades Respiratorias, Palma, Spain; f  The Institute of Medicine, University of Bergen, Bergen, Norway; g  Brigham and Women’s Hospital, and h  Harvard Medical School, Boston, Mass., USA; i  The University of British Columbia, Vancouver, B.C., Canada; j  GlaxoSmithKline, Research Triangle Park, Durham, N.C., USA; k  Cambridge Institute for Medical Research, University of Cambridge, Cambridge, and l  The University of Edinburgh, Edinburgh, UK; m  GlaxoSmithKline, King of Prussia, Pa., n  The University of Nebreska Medical Center, Omaha, Nebr., and o  Mayo Clinic, Rochester, Minn., USA; p  The Respiratory Section, Hvidovre Hospital, Hvidovre, and q  The University of Copenhagen, Copenhagen, Denmark; r  The Manchester Academic Health Science Center, University of Manchester, Manchester, UK; s  The University of Maastricht, Maastricht, The Netherlands nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associa- tions between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Un- derweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/ obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in un- Key Words Body composition · Chronic obstructive pulmonary disease · Fat free mass index · Fat mass index · Health status · Mortality Abstract Aims: The follow-up of the ECLIPSE study, a prospective lon- gitudinal study to identify and define parameters that pre- dict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related out- comes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 Received: January 24, 2013 Accepted after revision: May 22, 2013 Published online: November 7, 2013 Dr. Erica P.A. Rutten Center of Expertise for Chronic Organ Failure (Ciro+) Postbus 4080 6080 AB Haelen (The Netherlands) E-Mail ericarutten  @  ciro-horn.nl © 2013 S. Karger AG, Basel 0250–6807/13/0633–0239$38.00/0 www.karger.com/anm Downloaded by: Universiteit Maastricht 137.120.4.50 - 2/11/2014 2:28:58 PM