CHAPTER 4 INCREASED HEPATIC VLDL PRODUCTION IN THE ABSENCE OF HEPATOBILIARY LIPID SECRETION IN MDR2 P-GLYCOPROTEIN- DEFICIENT MICE Peter J Voshol, Rick Havinga, Kees Schoonderwoerd # , Lou B Agellon ‡ , Jobst Greeve † , Albert K Groen* and Folkert Kuipers Groningen University Institute for Drug Exploration, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Groningen, The Netherlands, # Department of Biochemistry, Erasmus University Rotterdam, The Netherlands, ‡ Department of Biochemistry, University of Alberta, Edmonton, Canada, † Medizinische Klinik, Universität-Krankenhaus Eppendorf, Hamburg, Germany and *Department of Gastrointestinal and Liver Diseases, Academic Medical Center, Amsterdam, The Netherlands. Submitted