Research Article Prognostic Value of Pentraxin-3 Level in Patients with STEMI and Its Relationship with Heart Failure and Markers of Oxidative Stress Marie Tomandlova, 1 Jiri Jarkovsky, 2 Josef Tomandl, 1 Lenka Kubkova, 3,4,5 Petr Kala, 4,5 Simona Littnerova, 2 Jana Gottwaldova, 5,6 Petr Kubena, 4,5 Eva Ganovska, 4,5 Martin Poloczek, 4,5 Jindrich Spinar, 3,4,5 Christian Mueller, 7 Alexandre Mebazaa, 8,9 Monika Pavkova Goldbergova, 10 and Jiri Parenica 3,4,5 1 Department of Biochemistry, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic 2 Institute of Biostatistics and Analyses, Masaryk University, 625 00 Brno, Czech Republic 3 Department of Cardiovascular Disease, International Clinical Research Center, St. Anne’s University Hospital, 656 91 Brno, Czech Republic 4 Department of Cardiology, University Hospital Brno, 625 00 Brno, Czech Republic 5 Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic 6 Department of Biochemistry, University Hospital Brno, 625 00 Brno, Czech Republic 7 Department of Internal Medicine, University Hospital, 4031 Basel, Switzerland 8 Department of Anesthesiology and Critical Care Medicine, Saint Luis Lariboisi` ere University Hospital, 75475 Paris, France 9 Cardiac Diseases and Biomarkers, INSERM UMR 942, Saint Luis Lariboisi` ere University Hospital, 75475 Paris, France 10 Institute of Pathological Physiology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic Correspondence should be addressed to Jiri Parenica; jiri.parenica@atlas.cz Received 2 February 2015; Revised 9 March 2015; Accepted 10 March 2015 Academic Editor: Stamatios heocharis Copyright © 2015 Marie Tomandlova et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Pentraxin-3 (PTX3) appears to have a cardioprotective efect through a positive inluence against postreperfusion damage. his study assesses the prognostic value of PTX3 level and its relationship with clinical parameters and markers of oxidative stress and nitric oxide metabolism in patients with ST-elevation myocardial infarction (STEMI). Methods. Plasma/serum levels of several biomarkers of inlammation and oxidative stress and nitrite/nitrate were assessed upon admission and 24 h ater STEMI onset in patients treated by primary percutaneous coronary intervention. Results. ROC analysis showed that plasma PTX3 at 24 h was a strong predictor of 30-day and 1-year mortality and independent predictor of combined end-point of let ventricle dysfunction or mortality in 1 year. he inlammatory response expressed by PTX3 had a signiicant relationship with age, heart failure, infarct size, impaired low in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-, 8-hydroxy-2  - deoxyguanosine, and nitrite/nitrate. Conclusions. Plasma PTX3 at 24 h ater STEMI onset is a strong predictor of 30-day and 1-year mortality. PTX3 as a single biomarker is comparable with currently used scoring systems (TIMI or GRACE) or B-type natriuretic peptide. PTX3 is also an independent predictor of combined end-point of let ventricle dysfunction or mortality in 1 year. 1. Introduction Inlammation has a crucial role during the acute phase and healing process ater acute myocardial infarction (MI). he inlammatory response is associated with the production of many mediators. Increased levels of C-reactive protein (CRP) during the MI have been demonstrated to be an independent negative prognostic factor [1, 2]. CRP activates complement via the classical pathway and thereby contributes to the lysis and removal of damaged myocardial cells [3]. An excessively Hindawi Publishing Corporation Disease Markers Volume 2015, Article ID 159051, 11 pages http://dx.doi.org/10.1155/2015/159051