Hindawi Publishing Corporation Journal of Lipids Volume 2013, Article ID 623420, 7 pages http://dx.doi.org/10.1155/2013/623420 Research Article Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects Jaydip Ray Chaudhuri, 1 K. Rukmini Mridula, 2 Alluri Anamika, 3 Demudu Babu Boddu, 4 Pradeep Kumar Misra, 5 A. Lingaiah, 6 Banda Balaraju, 5 and Vcs Srinivasarao Bandaru 1,7 1 Department of Neurology, Yashoda Hospital, Hyderabad, India 2 Department of Neurology, Nizam’s Institute of Medical Sciences, Hyderabad, India 3 Department of Biochemistry, Yashoda Hospital, Hyderabad, India 4 Department of Neurology, Caringhands Neurocenter, Vizag, India 5 Department of Medicine, Yashoda Hospital, Hyderabad, India 6 Director of Medical Services, Yashoda Hospital, Hyderabad, India 7 Department of Clinical Research, Yashoda Hospital, Hyderabad 500082, India Correspondence should be addressed to Vcs Srinivasarao Bandaru; rsbhandaru@gmail.com Received 5 September 2013; Revised 15 November 2013; Accepted 24 November 2013 Academic Editor: Maurizio Averna Copyright © 2013 Jaydip Ray Chaudhuri et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Vitamin D deiciency is widespread throughout the world. Several reports have incriminated vitamin D deiciency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deiciency of 25-hydroxyvitamin D and dyslipidemia. Aim. To investigate the association between 25-hydroxyvitamin D deiciency and dyslipidemia in Indian subjects. Methodology. We recruited 150 asymptomatic consecutive subjects from patients’ attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid proile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP). Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deiciency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deiciency of 25-hydroxyvitamin D was signiicantly associated with dyslipidemia ( = 0.0001), mean serum glucose ( = 0.0002) mean CRP ( = 0.04), and mean alkaline phosphatase ( = 0.01). Multivariate analysis showed that 25- hydroxyvitamin D deiciency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5). Conclusions. We found that deiciency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects. 1. Introduction Vitamin D deiciency is a common disorder, found in all age groups and in both genders [1, 2]. It is prevalent in various parts of the world including India [1–3] with an increased occurrence in high and low latitude countries [4]. Worldwide, the prevalence of vitamin D deiciency is 50% in elderly [5] and within Europe in 2%–30% of adults [6]. Serum 25-hydroxyvitamin D level is a sensitive measure of vitamin D status of an individual [1], and the prevalence of inadequate 25-hydroxyvitamin D is around 30% to 50% in the general population [7]. Recent reports have found that hypo 25-hydroxyvitamin D is associated with atherosclerosis [8], obesity [9], diabetes [10], hypertension [11], myocardial infarction [12], and stroke [13]. Dyslipidemia is a an independent risk factor for cardio- vascular and cerebrovascular diseases in individuals [14, 15]. Current studies have observed that low 25-hydroxyvitamin D is associated with dyslipidemia [16, 17]. We aim to investigate the relationship of circulating levels of 25-hydroxyvitamin D