CARBOHYDRATE RESEARCH zyxwvutsrqponm ELSEVIER zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA Carbohydrate Research 265 (1994) 291-298 zyxwvutsrqponmlkjihgfedcbaZYXWVUTSR Note zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONML The crystal and molecular structure of 4-cyanophenyl and 4-nitrophenyl / I-D-xylopyranosides Jean Yves Le Questel ‘, Nadine Mouhous-Riou, Serge Perez * zyxwvutsrq Ing&ierie Mokkulaire, zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA Institut National de la Recherche Agronomique, BP527, 44026 Nantes, France Received 9 M arch 1994; accepted 16 June 1994 Keywords: X-ray crystallography; Glycopyranoside; Xylopyranoside The synthesis of glycosaminoglycans may be induced by exogeneous primers such as P-D-xylopyranosyl derivatives. Although the biological process associated with such a synthesis have not been completely deciphered, there is some interest in elucidating the three-dimensional features that characterize these inducers. Actually some of them displaying antithrombotic activity have been already evaluated in an animal model [l]. The present note describes the crystal and molecular structure of 4-cyanophenyl (1) and 4-nitrophenyl j%D-xylopyranosides (2) which were respectively crystallized in methanol and a mixture of methanol and water at 20°C. Howo HO HOa HO zyxwvutsrqponmlkjihgfedcbaZYXWVUTS (1) % N (2) NO2 The positional and isotropic thermal parameters of 1 and 2 for the nonhydrogen atoms are given in Tables 1A and lB, and bond lengths and angles appear in Table 2. Views of 1 and 2, along with the numbering of the atops, are shown in Fig. ,l. The mean C-H distances for 1 and 2 are, respectively, 0.94 A (range 0.93 to 1.02 A), and * Corresponding author. 1 Present address: Laboratoire de Spectrochimie Moltculaire, Faculte des Sciences et Techniques, Univer- site de Nantes, France Elsevier Science B.V. SSDI 0008-6215(94)00233-9