1. Inside front cover (Editorial Board)  Page CO2 Regular paper 2. Combined effect of the methanol utilization (Mut) phenotype and gene dosage on recombinant protein production in Pichia pastoris fed-batch cultures  Pages 321-335 Oriol Cos, Alicia Serrano, José Luis Montesinos, Pau Ferrer, James M. Cregg and Francisco Valero Regular papers 3. Three forms of thermostable lactose-hydrolase from Thermus sp. IB-21: cloning, expression, and enzyme characterization  Pages 337-346 Sang Kee Kang, Kwang Keun Cho, Jong Kun Ahn, Jin Duck Bok, Seung Ha Kang, Jung Hee Woo, Hong Gu Lee, Seung Kwon You and Yun Jaie Choi 4. Investigations of the transfructosylation reaction by fructosyltransferase from B. subtilis NCIMB 11871 for the synthesis of the sucrose analogue galactosyl-fructoside  Pages 347-357 I.-E. Baciu, H.-J. Jördening, J. Seibel and K. Buchholz 5. Enhanced activity of recombinant β-secretase from Drosophila melanogaster S2 cells transformed with cDNAs encoding human β1,4- galactosyltransferase and Galβ1,4-GlcNAc α2,6-sialyltransferase  Pages 359-367 Kyung Hwa Chang, Jai Myung Yang, Hyung O.K. Chun and In Sik Chung 6. Application of Aspergillus niger-treated agrowaste residue and Glomus mosseae for improving growth and nutrition of Trifolium repens in a Cd- contaminated soil  Pages 369-378 A. Medina, N. Vassilev, J.M. Barea and R. Azcón Journal of Biotechnology Volume 116, Issue 4, Pages 321-426 (6 April 2005)