ORIGINAL ARTICLE EPIDEMIOLOGY AND GENETICS
Respiratory hypersensitivity reactions to NSAIDs in
Europe: the global allergy and asthma network (GA
2
LEN)
survey
J. S. Makowska
1,
*, P. Burney
2
, D. Jarvis
2
, T. Keil
3
, P. Tomassen
4
, J. Bislimovska
5
, G. Brozek
6
,
C. Bachert
4
, J. Baelum
7
, C. Bindslev-Jensen
8
, J. Bousquet
9
, P. J. Bousquet
9
, C. Kai-H akon
10
,
S. E. Dahlen
11
, B. Dahlen
12
, W. J. Fokkens
13
, B. Forsberg
14
, M. Gjomarkaj
15
, P. Howarth
16
,
E. Salagean
16
, C. Janson
17
, L. Kasper
18
, U. Kraemer
19,20
, C. Louiro
21
, B. Lundback
22
, J. Minov
5
,
E. Nizankowska-Mogilnicka
18
, N. Papadopoulos
23
, A. G. Sakellariou
23
, A. Todo-Bom
21
,
E. Toskala
24,25
, J. E. Zejda
6
, T. Zuberbier
26
& M. L. Kowalski
27
1
Department of Rheumatology, Medical University of L od z, L od z, Poland;
2
Department of Respiratory Epidemiology and Public Health,
Imperial College, London, UK;
3
Institute for Social Medicine, Epidemiology and Health Economics, Charit e – Universit€ atsmedizin Berlin,
Berlin, Germany;
4
Upper Airways Research Laboratory, Department of Otorhinolaryngology and Logopaedic-Audiologic Science, Ghent
University, Ghent, Belgium;
5
Institute for Occupational Health of R. Macedonia, University ‘‘Sts Cyril and Methodius’’ Skopje, Skopje,
Macedonia;
6
Department of Epidemiology, Faculty of Medicine, Medical University of Silesia, Katowice, Poland;
7
Department of
Occupational and Environmental Medicine, Odense University Hospital;
8
Department of Dermatology and Allergy Centre, Odense University
Hospital, Odense, Denmark;
9
Department of Respiratory Medicine, Montpellier University, Montpellier, France;
10
Oslo University Hospital,
Rikshospitalet,Oslo, Norway;
11
Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;
12
Unit of Heart and Lung
Diseases, Karolinska Institutet, Stockholm, Sweden;
13
Department of Otorhinolaryngology, Academic Medical Centre, University of
Amsterdam, Amsterdam, The Netherlands;
14
Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden;
15
Department of Respiratory Medicine, Institute of Biomedicine and Molecular Immunology, Palermo, Italy;
16
Department of Respiratory Cell
and Molecular Biology, University of Southampton, Southampton, UK;
17
Department of Medical Sciences, Respiratory, Allergy and Sleep
Research, Uppsala University, Uppsla, Sweden;
18
Department of Internal Medicine, Jagiellonian University Krakow, Krakow, Poland;
19
Environmental Health Research Institute, Heinrich Heine University, Dusseldorf, Germany;
20
Department of Dermatology and Allergy,
Technical University Munich, Munich, Germany;
21
Department of Immunology and Allergology, University Hospital Coimbra, Coimbra,
Portugal;
22
Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden;
23
Allergy Department, 2nd Paediatric Clinic,
University of Athens, Athens, Greece;
24
Department of Otorhinolaryngology and Finnish Institute of Occupational Health, Helsinki University
Hospital, Helsinki, Finland;
25
Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA;
26
Department of
Dermatology and Allergy, Charite´– Universitahtsmedizin Berlin, Berlin, Germany;
27
Department of Immunology, Rheumatology and Allergy,
Medical University of Lo ´ dz ´, Lo ´ dz ´, Poland
To cite this article: Makowska JS, Burney P, Jarvis D, Keil T, Tomassen P, Bislimovska J, Brozek G, Bachert C, Baelum J, Bindslev-Jensen C, Bousquet J,
Bousquet PJ, Kai-H akon C, Dahlen SE, Dahlen B, Fokkens WJ, Forsberg B, Gjomarkaj M, Howarth P, Janson C, Kasper L, Kraemer U, Louiro C, Lundback B,
Minov J, Nizankowska-Mogilnicka E, Papadopoulos N, Sakellariou AG, Todo-Bom A, Toskala E, Zejda JE, Zuberbier T, Kowalski ML. Respiratory hypersensitivity
reactions to NSAIDs in Europe: the global allergy and asthma network (GA
2
LEN) survey. Allergy 2016; DOI: 10.1111/all.12941.
Keywords
drug allergy; epidemiology; GA2LEN;
NSAIDs hypersensitivity.
Correspondence
Dr. Joanna Makowska, Department of
Rheumatology, Medical University of L od z,
Poland.
Tel.: +48426757309
Fax: +48426782292
E-mail: joanna.makowska@umed.lodz.pl
Accepted for publication 24 May 2016
Abstract
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the
most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis
was to estimate the prevalence of NSAID-induced respiratory symptoms in popu-
lation across Europe and to assess its association with upper and lower respira-
tory tract disorders.
Methods: The GA
2
LEN survey was conducted in 22 centers in 15 European coun-
tries. Each of 19 centers selected random samples of 5000 adults aged 15–74 from
their general population, and in three centers (Athens, Munich, Oslo), a younger
population was sampled. Questionnaires including questions about age, gender,
presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking
Abbreviations
CRS, chronic rhinosinusitis; EPOS, European position paper on Rhinosinusitis and Nasal Polyps; NERD, NSAID-exacerbated respiratory
disease; NIRHR, NSAID-induced respiratory hypersensitivity reaction; NSAIDs, nonsteroidal anti-inflammatory drugs.
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Allergy