International Journal of New Technology and Research (IJNTR) ISSN:2454-4116, Volume-2, Issue-4, April 2016 Pages 110-114 110 www.ijntr.org Abstract—Introduction Gastrointestinal stromal tumors GISTs are rare and fall into the category of non-epithelial tumors of the gastrointestinal tract , involving the stomach at a higher percentage (70 %). The purpose of this study , through a retrospective analysis of the observed cases , is to obtain data on the incidence , survival curve identification of prognostic and predictive parameters .The goal is to collect data concerning the natural history of GIST , 65% of patients were female, 35% male , mean age 64 years. Metastatic disease was assessed by cd171. In this study, n 11 (65 %) cases were L1 ( cd171 ) positive for smooth muscle tumors . Of which 8 with headquarters in the stomach, ileum en 3 . Investigations have been performed immunohistochemistry with CD117 , CD99 , ema . all enrolled patients tested positive for CD117 .Discussion Thread What are the prognostic factors of GiST is still a matter of debate, but the consensus conference (NIH) in 2001 defined BETHESTHA n 2 parameters which are: the size and mitotic index of 50 HP for the lesions found were reported as accidental the size ranged < 10mm to > 50mm . . . The study carried out shows that the markers are the key to the histological diagnosis of GIST malignancies in GIST have introduced anti-angiogenic therapy with administration of sunitinib at a dose of 50mg/die for 4 weeks every 6 . For the purpose of inhibiting tumor growth with a time of disease-free interval longer. It is evident that in the histological diagnosis of GIST are inserted reporting the results of molecular biology with immunohistochemical markers , in combination with mitotic index , and tumor size in order to define a complete risks MTS Index Terms—Intestinal Tumors Histology GIST. I. INTRODUCTION Gastrointestinal stromal tumors GISTs are rare, it is estimated that 1.5 / 100,000 cases with an average age 50-60 years. [1,2] Fall into the category of non-epithelial tumors of the gastrointestinal tract , involving the stomach at a higher percentage (70 %) and to a lesser extent the esophagus to the small intestine, colon , with a further minority who are interested in the omentum and mesentery retro peritoneum ( GiST extra gastrointestinal) .[3,4] Based on the characters and ultra structural immunohistochemistry if they identify a form smooth muscle , neural shape , and a mixed form an undifferentiated form ( Uncommitted ) . Then confirm that the differentiation from interstitial cells of Cajal, the latter CD117 receptor tyrosine kinase type III with oncogenic potential Giorgio Maria Paolo Graziano, Department of Sciences Medical Surgery and advanced technologies, University of Catania Medical School, Italy Giovanni Castelli .MD, Department of Sciences Medical Surgery and advanced technologies, University of Catania Medical School, Italy Prof Anthony Graziano , Department of Sciences Medical Surgery and advanced Technologies University of Catania Medical School, Italy Adress via S Sofia 86 Catania cap 95125 capable of activating phosphorylation that stimulates uncontrolled cell proliferation , activation of the KIT gene present in 80% of GIST ,[5,6] has introduced a new therapeutic approach for these tumors . The purpose of this study , through a retrospective analysis of the observed cases , is to obtain data on the incidence , survival curve identification of prognostic and predictive parameters . II. MATERIALS AND METHODS For the study were examined retrospectively patients referred from 1996-2004 at La II clinical surgery and specialist in the Department of Surgery II Policlinico Catania and from 2005 to 2014, including by consulting the database referred to the same period the Institute of Anatomy Pathology of AUO Policlinico Catania. The goal is to collect data from the copies of medical records of patients with transposition of all the information necessary for the examination of the following parameters: the TNM staging, location, size, Surgical treatment and chemotherapy, the recovery of the disease, survival, pathological anatomy, with tumor markers In biological tumor characteristics were evaluated all the information related only to malignancy or borderline, and were included mesenchymal neoplasm morphology consistent with the diagnosis of GIST, with reference to the natural history of GIST, and the incidence of prognostic parameters and predictive. The recruited patients were 20 cases referred n n 9 to living today and described in Table 1 (a),(b),(c) &(d). Fig 1: Nodule Immobilized to the Wall of the Yellow Stomach. Clinical and Molecular Anatomy of Gastrointestinal Stromal Tumors (GIST) Giorgio Maria Paolo Graziano, Giovanni Castelli, Prof Anthony Graziano