806 Pak J Med Sci 2012 Vol. 28 No. 5 www.pjms.com.pk INTRODUCTION Renal replacement therapy (dialysis & transplantation) for patients with end-stage renal disease (ESRD) is on the rise globally and the same epidemiologic trend is also being observed in Iran. 1,2 Three methods used for treatment of patients with ESRD are hemodialysis, peritoneal dialysis and renal transplantation. 3-6 Renal transplantation is the best option for treatment of the end-stage renal diseases 7-11 , and has more advantages than dialysis. 12-15 By renal drafting, patients with ESDR experience more survival rate and better quality of life in all ages. 7,10,13,14 In the previous studies of our center, survival rate in deceased donor 16 , living donor 17 and diabetics patients 18 were reported and 1. Amir Almasi-Hashiani, Department of Biostatistics and Epidemiology, Arak University of Medical Sciences, Arak, Iran. 2. Abdolreza Rajaeefard, Department of Epidemiology, 3. Jafar Hassanzade, Department of Epidemiology, 4. Heshmatollah Salahi, Shiraz Organ Transplantation Center, Namazi Hospital, 5. Davood Mehrabani, Stem Cell & Transgenic Technology Research Center, Pathology Dept., 6. Esmaeil Khedmati, University of Social Welfare and Rehabilitation, Tehran, Iran. 2-5: Shiraz University of Medical Sciences, Shiraz, Iran. Correspondence Amir Almasi-Hashiani, Email: amiralmasi@arakmu.ac.ir * Received for Publication: August 20, 2011 * 1 st Revision Received: September 22, 2011 * 2 nd Revision Received: April 16, 2012 * Final Revision Accepted: April 28, 2012 Original Article Graft survival rate in pediatric renal transplantation: A single center experience Amir Almasi-Hashiani 1 , Abdolreza Rajaeefard 2 , Jafar Hassanzade 3 , Heshmatollah Salahi 4 , Davood Mehrabani 5 , Esmaeil Khedmati 6 ABSTRACT Objective: Renal transplantation is the best option for treatment of the end-stage renal diseases and has more advantages than dialysis. The objective of this study was to determine the ten-year graft survival rate of renal transplantation and its contributing factors among a group of Iranian patients aged 18 years or younger. Methodology: In a retrospective cohort we aimed to study the ten-year graft survival rate of renal transplantation and its contributing factors among pediatric patients who have been transplanted from March 1999 to March 2009 in Shiraz Namazi Hospital Transplantation Center, southern Iran. Kaplan-Meier method was used to determine the survival rate, log rank test to compare survival curves, and Cox regression model to determine hazard ratios and to model variables affecting survival. Results: The 1, 3, 5, 7 and 10 year-graft survival rates were 96.8, 88.8, 82.8, 78.1, 78.1 percent, respectively. Cox regression model revealed that the duration of hospitalization was one of the important factors in graft survival rate in renal transplantation. Conclusion: In this study, the 10 year-graft survival rate for pediatric renal transplantation was 78.1%. Graft survival was signiicantly related to hospital stay after the operation. Donor source, cold ischemia time, immunosuppressive drugs regimen, time to diuresis, and cause of ESRD did not inluence the survival rate. KEYWORDS: Survival rate, Pediatric renal transplantation, Cox regression model, Kaplan-Meier. Grant Support & Financial Disclosures: Shiraz University of Medical Sciences, Shiraz, Iran. Pak J Med Sci October - December 2012 Vol. 28 No. 5 806-811 How to cite this article: Almasi-Hashiani A, Rajaeefard A, Hassanzade J, Salahi H, Mehrabani D, Khedmati E. Graft survival rate in pediatric renal transplantation: A single center experience. Pak J Med Sci 2012;28(5):806-811