Alterations in Biochemical Parameters During Subacute Toxicity of Fluoride Alone and in Conjunction with Aluminum Sulfate in Goats Vinay Kant & Anil Kumar Srivastava & Pawan Kumar Verma & Rajinder Raina Received: 25 September 2008 / Accepted: 19 December 2008 / Published online: 17 January 2009 # Humana Press Inc. 2009 Abstract Fluoride toxicity is a serious health problem in many parts of the globe. In present study, sodium fluoride at 20 mg/kg alone and in conjunction with aluminum sulfate at 150 mg/kg was administered orally daily for 30 days in healthy goats of group 1 and 2, respectively, to access the alterations in the various biochemical parameters during subacute toxicity of fluoride alone and in conjunction with aluminum sulfate. In Group 1, significant alterations in plasma glucose, blood urea nitrogen (BUN), creatinine, total protein, albumin, globulin, albumin/globulin ratio, magnesium, and sodium were observed on different days of exposure from their pre-exposure values. However, no significant changes were observed in plasma calcium, phosphorus, and potassium on different days of exposure of sodium fluoride. Similar type of biochemical alterations were noticed in the goats of Group 2 except BUN, total protein magnesium, and sodium. On the basis of results, it could be concluded that sodium fluoride alone and in conjunction with aluminum sulfate produced significant alterations in the various biochemical parameters of the body. Keywords Biochemical parameters . Aluminum sulfate . Goats . Sodium fluoride . Subacute toxicity Biol Trace Elem Res (2009) 130:20–30 DOI 10.1007/s12011-008-8311-8 Part of M.V.Sc. research conducted in Division of Pharmacology and Toxicology, F.V.Sc. and A.H., SKUAST-J, R.S. Pura, Jammu-181102, J&K, INDIA. V. Kant (*) Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SKUAST-J, R.S. Pura, Jammu 181102 J&K, India e-mail: drvinaykant2001@yahoo.co.in A. K. Srivastava National Dairy Research Institute, Karnal, India P. K. Verma : R. Raina Division of Pharmacology and Toxicology, SKUAST-J, R.S. Pura, Jammu, India