Novel compound, CH-223191, prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor SUN-HEE KIM, ELLEN C HENRY, DONG-KYU KIM , YUN-HEE KIM, KUM JOO SHIN, MYOUNG SOOK HAN, TAEHOON G. LEE, JONG-KU KANG, THOMAS A GASIEWICZ, SUNG HO RYU and PANN-GHILL SUH School of Environmental Science and Engineering (S.H.K., K.J.S., S.H.R. and P.G.S.), Department of Life Science (Y.H.K., S.H.R. and P.G.S.), SIGMOL Inc. (M.S.H. and T.G.L.), Pohang University of Science and Technology, Pohang, 790-784, South Korea Department of Laboratory Animal Medicine College of Veterinary Medicine, Chungbuk National University, Cheongju Chungbuk 361-763, South Korea (D. K. K., J. G. K.) Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York (E.C.H. and T.A.G.) Molecular Pharmacology Fast Forward. Published on March 15, 2006 as doi:10.1124/mol.105.021832 Copyright 2006 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on March 15, 2006 as DOI: 10.1124/mol.105.021832 at ASPET Journals on November 4, 2016 molpharm.aspetjournals.org Downloaded from