ORIGINAL ARTICLE Standardization of image quality across multiple centers by optimization of acquisition and reconstruction parameters with interim FDG-PET/CT for evaluating diffuse large B cell lymphoma Hiromitsu Daisaki • Ukihide Tateishi • Takashi Terauchi • Mitsuaki Tatsumi • Kazufumi Suzuki • Naoki Shimada • Hiroyuki Nishida • Akihiko Numata • Koji Kato • Koichi Akashi • Mine Harada Received: 11 September 2012 / Accepted: 4 December 2012 / Published online: 22 December 2012 Ó The Japanese Society of Nuclear Medicine 2012 Abstract Objective A multicenter trial is currently underway using FDG-PET/CT to evaluate diffuse large B cell lymphoma in Japan (JSCT NHL10). Standardization of the image quality between the participating centers is a fundamental aspect of the study. Within the framework of JSCT NHL10, stan- dardization of the image quality was attempted by opti- mizing the acquisition and reconstruction conditions using mid-therapy FDG-PET/CT for diffuse large B cell lymphoma. This report describes the procedures and results of this attempt. Methods The acquisition protocols and imaging quality were initially determined at each center and again after modification. The image quality was based on performance with an 18 F-filled National Electrical Manufacturers Association standards body phantom. We determined that the acquisition duration and reconstruction parameters of each scanner evaluated were in compliance with the Present Address: H. Daisaki (&) Nihon Medi-Physics Co., Ltd., Tokyo, Japan e-mail: hdaisaki@gmail.com H. Daisaki Á T. Terauchi Á N. Shimada Screening Technology and Development Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan T. Terauchi e-mail: tterauch@ncc.go.jp N. Shimada e-mail: nashimad@ncc.go.jp U. Tateishi Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan e-mail: utateish@yokohama-cu.ac.jp M. Tatsumi Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan e-mail: m-tatsumi@radiol.med.osaka-u.ac.jp K. Suzuki Department of Radiology, Dokkyo Medical University Hospital, Tochigi, Japan e-mail: kazufumi@dokkyomed.ac.jp H. Nishida Division of Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan e-mail: nishida@fbri.org A. Numata Á K. Kato Á K. Akashi Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan e-mail: akihiko@intmed1.med.kyushu-u.ac.jp K. Kato e-mail: kojikato@intmed1.med.kyushu-u.ac.jp K. Akashi e-mail: akashi@med.kyushu-u.ac.jp M. Harada National Hospital Organization, Omuta Hospital, Omuta, Japan e-mail: mharada@karatsu.saga.med.or.jp M. Harada Japan Study Group for Cell Therapy and Transplantation, Tochigi, Japan 123 Ann Nucl Med (2013) 27:225–232 DOI 10.1007/s12149-012-0676-2