International Journal of Cardiology 46 (1994) 175-178 Outcome of patients with diabetes and unstable angina. A subgroup analysis in the Spanish Multicentre Trial of trifusal in unstable angina Juan C. Garcia-Rubira*a, Jose M. Cruz”, Victor Lbpez”, Leandro Plazab, Juan C. Navasc, Grupo de Estudio de1 Trifusal en la Angina Inestable zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONM ‘Vnidad Coronaria. University Hospital Virgen Macarena, Avenida Doctor Fedriani 3, E-41009, Seville, Spain blnstituto de la Salud Carlos III, Madrid, Spain % Vriach d Cia Laboratories, Barcelona, Spain Received 24 March 1994; revision accepted 10 May 1994 Ahtract We analyzed the clinical characteristics of the 58 diabetic and 218 nondiabetic patients enrolled in the Spanish multicentre trial of trifusal in unstable angina. After 6 months of follow-up, 25 suffered from myocardial infarction or death, 10 of which were diabetics (17.2?/0) and 15 nondiabetics (6.9%) (P = 0.0146). This difference remained signifi- cant after multivariate analysis. We conclude that diabetes is an independent predictor of adverse outcome in patients with medically treated unstable angina . Keywordr: Diabetes; Coronary heart disease; Unstable angina 1. Introduction Patients with diabetes have an increased risk for cardiovascular events compared to nondiabetic in- dividuals, and this increase cannot be completely explained by the association with other health de- fects [ 1,2,3]. The purpose of this analysis was to verify if diabetes is also a predictor of poor out- * Corresponding author. come in patients with unstable angina treated with standard therapy. 2. Methods From April 1987 to December 1990, 281 pa- tients with unstable angina were enrolled in the Spanish Multicentre Trial ‘Estudio de1 Trifusal en la Angina Inestable’ [4], in which they were ran- domly assigned to the antiplatelet agent trifusal or placebo. Patients I 70 years admitted to the parti- 0167-5273&M/$07.00 0 1994 Elsevier science Ireland Ltd. Ail rights reserved SSDI 0167-5273(94)02089-Z