ISSN No:2321 – 8630, V – 2, I – 1, 2015 Journal Club for Pharmaceutical Sciences (JCPS) Manuscript No: JCPS/RES/2015/28, Received On: 22/02/2015 , Accepted On : 24/02/2015, Published On: 19/04/2015 RESEARCH ARTICLE © All Rights Reserved by “Journals Club & Co.” 1 Development & Evaluation of Satranidazole Nano Particulate Mucoadhesive System for Periodontitis Urooj A. Khan 1 , Usama Ahmad 2 , M. Usama Ashhar 1 , Md. Noushad Javed 1 , Gaurav K. Jain 1* , Farhan J. Ahmad 1 1 Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India 2 Nanopharmaceutical & Drug Delivery Research Lab, Faculty of Pharmacy, Integral University, Lucknow-226026, India ABSTRACT Emergence of nanotechnology in medicine has revolutionized the pharmaceutical industry.It has already cleared many hurdles associated with various delivery systems such as conventional methods, microspheres and other microparticulate systems. Recent development in nano drug delivery systems has proved to be efficacious in the therapeutic management strategies for dental disorders. The effective treatment for periodontal disease has been limited due to inability of earlier formulations to remain intact at the site of action, thereby reducing the duration of action. In this research work an attempt has been taken to develop a mucoadhesive nano particulate system of Satranidazole (SZ), a potent antimicrobial agent effective against various micro-organisms in dental disorders. Effect of two preparation methods for polymeric nanoparticles have been investigated to analyze their role on mean particle size (MPS), polydispersity index (PI), zeta potential and encapsulation efficiency (EE). Influence of solvent system, stabilizer and polymer concentration were optimized for developing a robust formulation. The prepared nanoparticles were coated with a mucoadhesive polymer to provide a prolonged retention at desired site, thereby increasing the duration of action. The results indicate that uncoated satranidazole nanoparticles exhibited smaller particle size & higher encapsulation efficiency as compared to coated nanoparticles, however, results of in-vitro release indicate that coated nanoparticles had much better release profiles as compared to uncoated nanoparticles. KEYWORDS Satranidazole, Nano Particulate System, Periodontal Disease, Mucoadhesion INTRODUCTION Periodontal disease is a collective term ascribed to a number of pathological conditions characterized by degeneration and inflammation of gums, periodontal ligaments, alveolar bone and dental cementum (1) . Treatment method includes use of chewable delivery systems such as *Address for Correspondence: Gaurav K. Jain, Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. Email: drgkjain@gmail.com