ISSN: 2320-5407 Int. J. Adv. Res. 4(10), 2132-2140 2132 Journal Homepage: - www.journalijar.com Article DOI: 10.21474/IJAR01/2031 DOI URL: http://dx.doi.org/10.21474/IJAR01/2031 RESEARCH ARTICLE EXPRESSION OF SERUM CYTOKINE( IL-17) AND OXIDATIVE STRESS MARKER (GSH) IN IRAQI PREGNANT WOMEN WITH PRE-ECLAMPSIA. Israa A. Abdul Kareem (MBChB MS.c FICMS) 1 , Enas Adnan A Al-Kazaaly (MBChB, CABOG, FIBMS) 2 and Mohammed I. Hamzah Ph.D 3 . 1. Chemical pathology, College of pharmacy ,Al-Nahrain University. 2. Gynecology and obstetrics, College of Medicine , Al-Nahrain University. 3. Clinical chemistry, College of Medicine , Al-Nahrain University. …………………………………………………………………………………………………….... Manuscript Info Abstract ……………………. ……………………………………………………………… Manuscript History Received: 27 September2016 Final Accepted: 12 October 2016 Published: October 2016 Key words:- preeclampsia,interleukine-17 and GSH Background:- Pre-eclampsia is the second leading cause of maternal morbidity and mortality in the United States. Infants born to affected mothers face a five-fold increase in death rate. Sometimes referred to as toxaemia by the lay public, Pre-eclampsia is defined as the presence of hypertension (systolic blood pressure [BP] ≥140mmHg or diastolic BP≥90 mmHg), and proteinuria exceeding 0.3 g/day after the twentieth week of pregnancy in a previously normotensive non protein uric woman.preeclampsia is associated with chronic inflammation and placental oxidative stress (ROS), chronic IL-17 increases blood pressure, which though exerts a host-defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. Objectives:- To evaluate natural antioxidant level (GSH) & IL-17 in the sera of pregnant women with preeclampsia. Patients / Methods:- The target subjects of this descriptive cross- sectional study consisted of 60 pregnant (30 pregnant women with preeclampsia (severe and mild to moderate) and 30 (non- preeclamptic) pregnant women (control) diagnosed by a specialist Obstetrics and Gynecology, aged 15 to 40 years who were recruited from the outpatient clinic of of Obstetrics and Gynecology at the Al- Imamain Al-khadimain city hospital,between December of 2014 and the November 2015.Serum IL-17 was estimated using an Enzyme- Linked Immunosorbant Assay ( ELISA ) technique.while GSH was measured by Burtis and Ashwood. Results:- Serum levels of IL-17 was statistically significantly elevated in the patients with preclampsia (severe and mild to moderate) compared to normotensive pregnant women ( p < 0.001 ) and a significant difference was detected as well within preclamptic patients groups severe with mild to moderate (p< 0.05) . A significant decrease (P<0.001) is observed in the level of serum Glutathione (GSH) of preclampsia pregnancy (severe and mild to moderate) when compared with normotensive pregnant women , also a significant difference within preclamptic patients (P<0.01)was observed. Corresponding Author:- Israa A. Abdul Kareem. Address:- Chemical pathology, College of pharmacy ,Al-Nahrain University.