© Asian Journal of Biomedical and Pharmaceutical Sciences, 2015. Association of age related severity in oxidative stress and blood urea nitrogen levels in patients with dementia: A coastal Karnataka study Abhishek Chaturvedi 1* , Archana Natarajan 2 , Vivek Sharma 2 , Vanishree Bambrana 2 , Nagalakshmi Yaparthy 2 , Jeevan K Shetty 3 , Devaramane Virupaksha 4 , Panambur V Bhandary 4 , Mungli Prakash 5 1 Department of Biochemistry, Melaka Medical College, Manipal University, Manipal-576104, India. 2 Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal-576104, India 3 Department of Biochemistry, RAK College of Medical Sciences, RAKMHSU, Ras Al Khaimah, UAE 4 Department of Psychiatry, Dr. A V Baliga memorial hospital, Doddanagudde, Udupi, India 5 Department of Biochemistry and Genetics, St Matthew’s University, School of Medicine, Grand Cayman, Cayman Islands, BWI. Introduction: It has been shown that occurrence of dementia increases with age. Oxi- dative stress has been implicated in the development of dementia. In the present work, we measured malondialdehyde (MDA), total thiols and other routine biochemical pa- rameters in dementia patients to establish a relationship between them. Method: Study was carried out in 51 dementia patients and 30 healthy controls. he serum from patients and controls were analyzed for MDA, protein thiols, lipid proile, RBS and BUN by spectrophotometric methods. Results: here was a signiicant increase in MDA level (p<0.001) and blood urea ni- trogen (BUN) level (p<0.001) and decrease in thiols levels (p<0.001) in dementia pa- tients compared to healthy controls. here was a positive correlation between levels of MDA and age of patients (r=0.542, p<0.001). Negative correlation was observed between total thiols and age of the patients. (r= - 0.420, p<0.05) and total thiols and blood urea nitrogen (r= -0.343, p<0.01). Conclusion: In line with previous studies, our study has shown increased oxidative damage in dementia patients irrespective of their etiology. his study also explores the relationship between increased BUN concentration and dementia. Key words: Dementia, oxidative stress, MDA, hiols, BUN. ABSTRACT : Dementia is referred to as a group of chronic disor- ders which is characterized by memory loss, devel- opment of multiple cognitive defects seen in cases of altered physiological conditions. hese altered condi- tions are marked by changes in the personality of an individual accompanied by loss of intellectual func- tion. he alteration of the physiological conditions leading to dementia could be due to any medication or multiple etiology leading to social and occupation- al dysfunction. (1) It has been studied that dementia becomes more frequent in occurrence with age. It has got a prevalence of 5%-10% in those above 65 years of age and 20% in those over 80 years of age. (2) here are several factors and conditions that can lead to de- mentia. hese can be, Alzheimer’s disease (AD), vas- cular disease, dementia with Lewy bodies, alcoholic dementia, Creutzfeldt–Jakob disease, Parkinson’s disease, genetic or a metabolic disease and toxic or a traumatic disease. Our study was conducted to show that oxidative stress was a predisposition factor of dementia. Oxidative stress helps in promoting the pathogenesis of demen- tia. (3) Oxidative stress will occur in a condition where there is an imbalance in the oxidant and anti-oxi- *Corresponding author: Abhishek Chaturvedi Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal University, Manipal-576104 E-mail: biochem.abhishek@gmail.com Telephone: +919844681761 Conlict of interest: Authors reported none doi: 10.15272/ajbps.v5i44.688 INTRODUCTION: Recived on:10/04/2015 Accepted on: 25/04/2015 Published on: 25/05/2015 QR Code for mobile Article Info O pen A ccess Literati Research Article